Multivariate genetic analysis of apo AI concentration and HDL subfractions: Evidence for major locus pleiotropy

J. Blangero, S. Williams‐Blangero, M. C. Mahaney

    Research output: Contribution to journalArticle

    20 Scopus citations


    A major locus influencing apolipoprotein AI (apo AI) serum levels was detected using data from the Donner Laboratory Family Study. This locus accounts for 46% of the phenotypic variability in apo AI levels. Multivariate segregation analysis revealed that this major locus also has significant pleiotropic effects on the relative distribution of high density lipoproteins. © 1993 Wiley‐Liss, Inc.

    Original languageEnglish (US)
    Pages (from-to)617-622
    Number of pages6
    JournalGenetic epidemiology
    Issue number6
    StatePublished - 1993



    • multivariate segregation analysis
    • quantitative traits
    • statistical genetics

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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