Multivariate genetic analysis of apo AI concentration and HDL subfractions

Evidence for major locus pleiotropy

J. Blangero, S. Williams-Blangero, M. C. Mahaney

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A major locus influencing apolipoprotein AI (apo AI) serum levels was detected using data from the Donner Laboratory Family Study. This locus accounts for 46% of the phenotypic variability in apo AI levels. Multivariate segregation analysis revealed that this major locus also has significant pleiotropic effects on the relative distribution of high density lipoproteins.

Original languageEnglish (US)
Pages (from-to)617-622
Number of pages6
JournalGenetic Epidemiology
Volume10
Issue number6
DOIs
StatePublished - 1993
Externally publishedYes

Fingerprint

Apolipoprotein A-I
Multivariate Analysis
HDL Lipoproteins
Serum

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Multivariate genetic analysis of apo AI concentration and HDL subfractions : Evidence for major locus pleiotropy. / Blangero, J.; Williams-Blangero, S.; Mahaney, M. C.

In: Genetic Epidemiology, Vol. 10, No. 6, 1993, p. 617-622.

Research output: Contribution to journalArticle

Blangero, J. ; Williams-Blangero, S. ; Mahaney, M. C. / Multivariate genetic analysis of apo AI concentration and HDL subfractions : Evidence for major locus pleiotropy. In: Genetic Epidemiology. 1993 ; Vol. 10, No. 6. pp. 617-622.
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