Multipoint oligogenic linkage analysis of quantitative traits

John Blangero, Laura Almasy

Research output: Contribution to journalArticle

174 Citations (Scopus)

Abstract

We present an overview of pedigree-based variance component linkage methods and discuss their extension to oligogenic inheritance. As an example, oligogenic linkage analyses were performed using the quantitative trait Q4 from the GAW10 simulated data set. A strategy involving sequential oligogenic analyses was found to have increased power to detect the three quantitative trait loci (QTL) influencing Q4 when compared to the classical marginal approach of requiring each locus to have a lod score ≤ 3. However, it is shown that requiring conditional lod scores ≤ 3 in the sequential analyses may be overly conservative and alternative criteria for the acceptance of multilocus models are discussed.

Original languageEnglish (US)
Pages (from-to)959-964
Number of pages6
JournalGenetic Epidemiology
Volume14
Issue number6
DOIs
StatePublished - 1997
Externally publishedYes

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Lod Score
Multifactorial Inheritance
Quantitative Trait Loci
Pedigree
Datasets

Keywords

  • Complex pedigrees
  • Statistical genetics
  • Variance components

ASJC Scopus subject areas

  • Genetics(clinical)
  • Epidemiology

Cite this

Multipoint oligogenic linkage analysis of quantitative traits. / Blangero, John; Almasy, Laura.

In: Genetic Epidemiology, Vol. 14, No. 6, 1997, p. 959-964.

Research output: Contribution to journalArticle

Blangero, John ; Almasy, Laura. / Multipoint oligogenic linkage analysis of quantitative traits. In: Genetic Epidemiology. 1997 ; Vol. 14, No. 6. pp. 959-964.
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