Multiplicity of DNA end resection machineries in chromosome break repair

Hengyao Niu; Steven Raynard; Patrick Sung

doi:10.1101/gad.1824209

Multiplicity of DNA end resection machineries in chromosome break repair

Hengyao Niu, Steven Raynard, Patrick Sung

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

DNA end resection is critical for chromosome break repair by homologous recombination and influences the efficiency of repair by nonhomologous DNA end joining. An elegant study by Sinha and colleagues (pp. 1423-1437) published in the June 15, 2009, issue of Genes & Development identified a novel mycobacterial DNA end resection protein complex, AdnAB, that harbors dual DNA motor and dual nuclease functions. Sinha and colleagues also demonstrated that the DNA end-binding protein complex Ku regulates the activity of AdnAB.

Original language	English (US)
Pages (from-to)	1481-1486
Number of pages	6
Journal	Genes and Development
Volume	23
Issue number	13
DOIs	https://doi.org/10.1101/gad.1824209
State	Published - Jul 1 2009
Externally published	Yes

Keywords

ATP-dependent nuclease
DNA repair
Double-strand breaks
Helicase
Molecular ruler

ASJC Scopus subject areas

General Medicine

Access to Document

10.1101/gad.1824209

Cite this

@article{13de5a3f8b044368a894f33b89a157a1,

title = "Multiplicity of DNA end resection machineries in chromosome break repair",

abstract = "DNA end resection is critical for chromosome break repair by homologous recombination and influences the efficiency of repair by nonhomologous DNA end joining. An elegant study by Sinha and colleagues (pp. 1423-1437) published in the June 15, 2009, issue of Genes \& Development identified a novel mycobacterial DNA end resection protein complex, AdnAB, that harbors dual DNA motor and dual nuclease functions. Sinha and colleagues also demonstrated that the DNA end-binding protein complex Ku regulates the activity of AdnAB.",

keywords = "ATP-dependent nuclease, DNA repair, Double-strand breaks, Helicase, Molecular ruler",

author = "Hengyao Niu and Steven Raynard and Patrick Sung",

year = "2009",

month = jul,

day = "1",

doi = "10.1101/gad.1824209",

language = "English (US)",

volume = "23",

pages = "1481--1486",

journal = "Genes and Development",

issn = "0890-9369",

publisher = "Cold Spring Harbor Laboratory Press",

number = "13",

}

TY - JOUR

T1 - Multiplicity of DNA end resection machineries in chromosome break repair

AU - Niu, Hengyao

AU - Raynard, Steven

AU - Sung, Patrick

PY - 2009/7/1

Y1 - 2009/7/1

N2 - DNA end resection is critical for chromosome break repair by homologous recombination and influences the efficiency of repair by nonhomologous DNA end joining. An elegant study by Sinha and colleagues (pp. 1423-1437) published in the June 15, 2009, issue of Genes & Development identified a novel mycobacterial DNA end resection protein complex, AdnAB, that harbors dual DNA motor and dual nuclease functions. Sinha and colleagues also demonstrated that the DNA end-binding protein complex Ku regulates the activity of AdnAB.

AB - DNA end resection is critical for chromosome break repair by homologous recombination and influences the efficiency of repair by nonhomologous DNA end joining. An elegant study by Sinha and colleagues (pp. 1423-1437) published in the June 15, 2009, issue of Genes & Development identified a novel mycobacterial DNA end resection protein complex, AdnAB, that harbors dual DNA motor and dual nuclease functions. Sinha and colleagues also demonstrated that the DNA end-binding protein complex Ku regulates the activity of AdnAB.

KW - ATP-dependent nuclease

KW - DNA repair

KW - Double-strand breaks

KW - Helicase

KW - Molecular ruler

UR - https://www.scopus.com/pages/publications/67649635451

UR - https://www.scopus.com/inward/citedby.url?scp=67649635451&partnerID=8YFLogxK

U2 - 10.1101/gad.1824209

DO - 10.1101/gad.1824209

M3 - Review article

C2 - 19571177

AN - SCOPUS:67649635451

SN - 0890-9369

VL - 23

SP - 1481

EP - 1486

JO - Genes and Development

JF - Genes and Development

IS - 13

ER -

Multiplicity of DNA end resection machineries in chromosome break repair

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this