Multiplicity of DNA end resection machineries in chromosome break repair

Hengyao Niu, Steven Raynard, Patrick Sung

Research output: Contribution to journalReview article

28 Scopus citations

Abstract

DNA end resection is critical for chromosome break repair by homologous recombination and influences the efficiency of repair by nonhomologous DNA end joining. An elegant study by Sinha and colleagues (pp. 1423-1437) published in the June 15, 2009, issue of Genes & Development identified a novel mycobacterial DNA end resection protein complex, AdnAB, that harbors dual DNA motor and dual nuclease functions. Sinha and colleagues also demonstrated that the DNA end-binding protein complex Ku regulates the activity of AdnAB.

Original languageEnglish (US)
Pages (from-to)1481-1486
Number of pages6
JournalGenes and Development
Volume23
Issue number13
DOIs
StatePublished - Jul 1 2009
Externally publishedYes

Keywords

  • ATP-dependent nuclease
  • DNA repair
  • Double-strand breaks
  • Helicase
  • Molecular ruler

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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