Mutations that extend nematode longevity by interference with IGF-I/insulin sensing pathways also lead to resistance to multiple forms of stress. Here, we report that skin-derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed aspects of aging, are resistant to multiple forms of cellular stress, including UV light, heat, paraquat, H2O2, and the toxic metal cadmium. The findings suggest that increases in cellular resistance to stress may mediate extended longevity in mammals.
|Original language||English (US)|
|Number of pages||2|
|Journal||The FASEB journal : official publication of the Federation of American Societies for Experimental Biology|
|State||Published - Aug 2003|
ASJC Scopus subject areas
- Molecular Biology