Multiplex stress resistance in cells from long-lived dwarf mice.

Shin Murakami; Adam Salmon; Richard A. Miller

doi:10.1096/fj.02-1092fje

Multiplex stress resistance in cells from long-lived dwarf mice.

Shin Murakami, Adam Salmon, Richard A. Miller

Research output: Contribution to journal › Article › peer-review

178 Scopus citations

Abstract

Mutations that extend nematode longevity by interference with IGF-I/insulin sensing pathways also lead to resistance to multiple forms of stress. Here, we report that skin-derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed aspects of aging, are resistant to multiple forms of cellular stress, including UV light, heat, paraquat, H2O2, and the toxic metal cadmium. The findings suggest that increases in cellular resistance to stress may mediate extended longevity in mammals.

Original language	English (US)
Pages (from-to)	1565-1566
Number of pages	2
Journal	The FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume	17
Issue number	11
DOIs	https://doi.org/10.1096/fj.02-1092fje
State	Published - Aug 2003
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Biochemistry
Molecular Biology
Genetics

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abstract = "Mutations that extend nematode longevity by interference with IGF-I/insulin sensing pathways also lead to resistance to multiple forms of stress. Here, we report that skin-derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed aspects of aging, are resistant to multiple forms of cellular stress, including UV light, heat, paraquat, H2O2, and the toxic metal cadmium. The findings suggest that increases in cellular resistance to stress may mediate extended longevity in mammals.",

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AB - Mutations that extend nematode longevity by interference with IGF-I/insulin sensing pathways also lead to resistance to multiple forms of stress. Here, we report that skin-derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed aspects of aging, are resistant to multiple forms of cellular stress, including UV light, heat, paraquat, H2O2, and the toxic metal cadmium. The findings suggest that increases in cellular resistance to stress may mediate extended longevity in mammals.

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Multiplex stress resistance in cells from long-lived dwarf mice.

Abstract

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