Multiplex stress resistance in cells from long-lived dwarf mice.

Shin Murakami, Adam Salmon, Richard A. Miller

Research output: Contribution to journalArticle

163 Scopus citations

Abstract

Mutations that extend nematode longevity by interference with IGF-I/insulin sensing pathways also lead to resistance to multiple forms of stress. Here, we report that skin-derived fibroblasts from Snell dwarf mice, already known to show increased longevity and delayed aspects of aging, are resistant to multiple forms of cellular stress, including UV light, heat, paraquat, H2O2, and the toxic metal cadmium. The findings suggest that increases in cellular resistance to stress may mediate extended longevity in mammals.

Original languageEnglish (US)
Pages (from-to)1565-1566
Number of pages2
JournalThe FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Volume17
Issue number11
StatePublished - Aug 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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