Knowledge gained over the last 3 decades allows us to target chemoprevention strategies to events involved in the initiation of carcinogenesis by diverse carcinogens. A mechanism common to most agents is the induction of DNA damage by electrophilic intermediates. Strategies are described that block the metabolic production of the electrophiles, enhance natural detoxification mechanisms, or provide a nontoxic nucleophile to scavenge the electrophilic, ultimate carcinogen. These 3 strategies are complementary and independent of those that affect the promotion or progression phases of carcinogenesis. Multifocal strategies may be employed in the future to synergistically block chemical carcinogenesis.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Dec 1 1995|
ASJC Scopus subject areas
- Cancer Research