Multiple strategies for the inhibition of cancer induction

M. C. MacLeod, T. J. Slaga

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Knowledge gained over the last 3 decades allows us to target chemoprevention strategies to events involved in the initiation of carcinogenesis by diverse carcinogens. A mechanism common to most agents is the induction of DNA damage by electrophilic intermediates. Strategies are described that block the metabolic production of the electrophiles, enhance natural detoxification mechanisms, or provide a nontoxic nucleophile to scavenge the electrophilic, ultimate carcinogen. These 3 strategies are complementary and independent of those that affect the promotion or progression phases of carcinogenesis. Multifocal strategies may be employed in the future to synergistically block chemical carcinogenesis.

Original languageEnglish (US)
Pages (from-to)492-498
Number of pages7
JournalCancer Bulletin
Issue number6
StatePublished - Dec 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research


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