Multiple sclerosis. Gadolinium enhancement in MR imaging

R. I. Grossman, F. Gonzalez-Scarano, S. W. Atlas, S. Galetta, D. H. Silberberg

Research output: Contribution to journalArticlepeer-review

227 Scopus citations


Magnetic resonance (MR) images - both nonenhanced and enhanced with gadolinium DTPA/dimeglumine (Gd) - were compared with high-iodine (88.1 g I) computed tomographic (HICT) scans in demonstrating lesions in 15 patients known to have multiple sclerosis (MS). T1-weighted, mixed (T1, proton density, and T2), and T2-weighted MR pulse sequences were used. More than 20 lesions in each of 14 patients were demonstrated by pre-Gd mixed images and T2WI. Nine patients had clinical symptoms of active disease. Gd-enhanced T1WI showed at least one lesion that appeared to correspond with newly reported symptoms or signs. In addition, three clinically stable patients showed enhancement. Enhancement was best seen on 3-minute T1WI. HICT scans showed enhancement in four of the nine patients with active disease and in none of five clinically stable patients. Gd-enhanced MR imaging appears to be more sensitive than HICT in the detection of the transient abnormalities of the blood-brain barrier that occur in patients with active MS and appears capable of distinguishing active lesions that may correspond to the anatomic regions responsible for abnormal clinical findings.

Original languageEnglish (US)
Pages (from-to)721-725
Number of pages5
Issue number3
StatePublished - 1986

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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