Multiple sclerosis disease activity correlates with gadolinium‐enhanced magnetic resonance imaging

F. Gonzalez‐Scarano, Robert I. Grossman, Steve Galetta, Scott W. Atlas, Donald H. Silberberg

Research output: Contribution to journalArticlepeer-review

94 Scopus citations


Magnetic resonance imaging provides a method of visualizing multiple sclerosis plaques, but the age and activity of these plaques cannot be determined with routine magnetic resonance images. Gadolinium DTPA is a paramagnetic contrast agent that does not cross an intact blood–brain barrier. We studied 16 patients with multiple sclerosis, using magnetic resonance imaging, gadolinium‐enhanced magnetic resonance imaging, and computed tomographic scans. Gadolinium enhancement of multiple sclerosis plaques correlated with the clinical activity of the disease and corresponded anatomically with the symptoms and signs. We conclude that gadolinium enhancement of magnetic resonance images is a promising tool in the investigation of multiple sclerosis lesions and that it may provide a method for objective follow‐up in clinical trials.

Original languageEnglish (US)
Pages (from-to)300-306
Number of pages7
JournalAnnals of neurology
Issue number3
StatePublished - Mar 1987

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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