Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

B. Hille; D. J. Beech; L. Bernheim; A. Mathie; M. S. Shapiro; L. P. Wollmuth

doi:10.1016/0024-3205(95)00038-8

Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

B. Hille
, D. J. Beech
, L. Bernheim
, A. Mathie
, M. S. Shapiro
, L. P. Wollmuth

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

Muscarinic receptors depress Ca²⁺ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.

Original language	English (US)
Pages (from-to)	989-992
Number of pages	4
Journal	Life Sciences
Volume	56
Issue number	11-12
DOIs	https://doi.org/10.1016/0024-3205(95)00038-8
State	Published - Feb 10 1995
Externally published	Yes

Keywords

himbacine
muscarinic receptor
pertussis toxin
pirenzepine
sympathetic ganglion

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(95)00038-8

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@article{cddcf1fafde64e098147f7f4834b63fc,

title = "Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons",

abstract = "Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.",

keywords = "himbacine, muscarinic receptor, pertussis toxin, pirenzepine, sympathetic ganglion",

author = "B. Hille and Beech, \{D. J.\} and L. Bernheim and A. Mathie and Shapiro, \{M. S.\} and Wollmuth, \{L. P.\}",

note = "Funding Information: Our work has been generously supported by the National Institutes of M\&night Endowment for Neurosciences,a nd the W.M. Keck Foundation.",

year = "1995",

month = feb,

day = "10",

doi = "10.1016/0024-3205(95)00038-8",

language = "English (US)",

volume = "56",

pages = "989--992",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "11-12",

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TY - JOUR

T1 - Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

AU - Hille, B.

AU - Beech, D. J.

AU - Bernheim, L.

AU - Mathie, A.

AU - Shapiro, M. S.

AU - Wollmuth, L. P.

N1 - Funding Information: Our work has been generously supported by the National Institutes of M&night Endowment for Neurosciences,a nd the W.M. Keck Foundation.

PY - 1995/2/10

Y1 - 1995/2/10

N2 - Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.

AB - Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.

KW - himbacine

KW - muscarinic receptor

KW - pertussis toxin

KW - pirenzepine

KW - sympathetic ganglion

UR - https://www.scopus.com/pages/publications/0028941142

UR - https://www.scopus.com/pages/publications/0028941142#tab=citedBy

U2 - 10.1016/0024-3205(95)00038-8

DO - 10.1016/0024-3205(95)00038-8

M3 - Article

C2 - 10188803

AN - SCOPUS:0028941142

SN - 0024-3205

VL - 56

SP - 989

EP - 992

JO - Life Sciences

JF - Life Sciences

IS - 11-12

ER -

Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

Abstract

Keywords

ASJC Scopus subject areas

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