Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons

B. Hille, D. J. Beech, L. Bernheim, A. Mathie, M. S. Shapiro, L. P. Wollmuth

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.

Original languageEnglish (US)
Pages (from-to)989-992
Number of pages4
JournalLife Sciences
Volume56
Issue number11-12
DOIs
StatePublished - Feb 10 1995
Externally publishedYes

Keywords

  • himbacine
  • muscarinic receptor
  • pertussis toxin
  • pirenzepine
  • sympathetic ganglion

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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    Hille, B., Beech, D. J., Bernheim, L., Mathie, A., Shapiro, M. S., & Wollmuth, L. P. (1995). Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons. Life Sciences, 56(11-12), 989-992. https://doi.org/10.1016/0024-3205(95)00038-8