Multiple endocrine neoplasia type III

M. A. Nasir, R. W. Yee, K. L. Piest, C. A. Reasner

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The multiple endocrine neoplasia (MEN) syndromes are autosomally dominant inherited disorders in which hyperplastic or neoplastic changes occur in a wide variety of tissues. The specific syndromes are classified according to the endocrine glands affected. MEN type I consists of an aggregation of tumors of parathyroid, pancreatic, and pituitary glands. The association of medullary carcinoma of the thyroid (MCT) and pheochromocytoma is called MEN type II or type IIA, and if combined with mucosal neuromas, intestinal ganglioneuromatosis, and prominent corneal nerves, is named MEN type III or type IIB. Individuals afflicted with MEN type III are characterized by a marfanoid habitus, mucosal neuromas involving oral and ocular tissues, and a number of ophthalmologic findings including prominent corneal nerves, thickened eyelids, and subconjunctival neuromas. These features are easily recognized during the ocular exam, allowing the ophthalmologist to make an early diagnosis of this syndrome prior to the onset of life-threatening manifestations like medullary thyroid carcinoma and pheochromocytoma.

Original languageEnglish (US)
Pages (from-to)454-459
Number of pages6
JournalCornea
Volume10
Issue number5
StatePublished - 1991
Externally publishedYes

Fingerprint

Multiple Endocrine Neoplasia
Neuroma
Pheochromocytoma
Endocrine Glands
Multiple Endocrine Neoplasia Type 1
Parathyroid Glands
Pituitary Gland
Eyelids
Early Diagnosis
Neoplasms
Medullary Thyroid cancer

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Nasir, M. A., Yee, R. W., Piest, K. L., & Reasner, C. A. (1991). Multiple endocrine neoplasia type III. Cornea, 10(5), 454-459.

Multiple endocrine neoplasia type III. / Nasir, M. A.; Yee, R. W.; Piest, K. L.; Reasner, C. A.

In: Cornea, Vol. 10, No. 5, 1991, p. 454-459.

Research output: Contribution to journalArticle

Nasir, MA, Yee, RW, Piest, KL & Reasner, CA 1991, 'Multiple endocrine neoplasia type III', Cornea, vol. 10, no. 5, pp. 454-459.
Nasir MA, Yee RW, Piest KL, Reasner CA. Multiple endocrine neoplasia type III. Cornea. 1991;10(5):454-459.
Nasir, M. A. ; Yee, R. W. ; Piest, K. L. ; Reasner, C. A. / Multiple endocrine neoplasia type III. In: Cornea. 1991 ; Vol. 10, No. 5. pp. 454-459.
@article{63d40e3524bd42f8a935680d57f450d6,
title = "Multiple endocrine neoplasia type III",
abstract = "The multiple endocrine neoplasia (MEN) syndromes are autosomally dominant inherited disorders in which hyperplastic or neoplastic changes occur in a wide variety of tissues. The specific syndromes are classified according to the endocrine glands affected. MEN type I consists of an aggregation of tumors of parathyroid, pancreatic, and pituitary glands. The association of medullary carcinoma of the thyroid (MCT) and pheochromocytoma is called MEN type II or type IIA, and if combined with mucosal neuromas, intestinal ganglioneuromatosis, and prominent corneal nerves, is named MEN type III or type IIB. Individuals afflicted with MEN type III are characterized by a marfanoid habitus, mucosal neuromas involving oral and ocular tissues, and a number of ophthalmologic findings including prominent corneal nerves, thickened eyelids, and subconjunctival neuromas. These features are easily recognized during the ocular exam, allowing the ophthalmologist to make an early diagnosis of this syndrome prior to the onset of life-threatening manifestations like medullary thyroid carcinoma and pheochromocytoma.",
author = "Nasir, {M. A.} and Yee, {R. W.} and Piest, {K. L.} and Reasner, {C. A.}",
year = "1991",
language = "English (US)",
volume = "10",
pages = "454--459",
journal = "Cornea",
issn = "0277-3740",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

TY - JOUR

T1 - Multiple endocrine neoplasia type III

AU - Nasir, M. A.

AU - Yee, R. W.

AU - Piest, K. L.

AU - Reasner, C. A.

PY - 1991

Y1 - 1991

N2 - The multiple endocrine neoplasia (MEN) syndromes are autosomally dominant inherited disorders in which hyperplastic or neoplastic changes occur in a wide variety of tissues. The specific syndromes are classified according to the endocrine glands affected. MEN type I consists of an aggregation of tumors of parathyroid, pancreatic, and pituitary glands. The association of medullary carcinoma of the thyroid (MCT) and pheochromocytoma is called MEN type II or type IIA, and if combined with mucosal neuromas, intestinal ganglioneuromatosis, and prominent corneal nerves, is named MEN type III or type IIB. Individuals afflicted with MEN type III are characterized by a marfanoid habitus, mucosal neuromas involving oral and ocular tissues, and a number of ophthalmologic findings including prominent corneal nerves, thickened eyelids, and subconjunctival neuromas. These features are easily recognized during the ocular exam, allowing the ophthalmologist to make an early diagnosis of this syndrome prior to the onset of life-threatening manifestations like medullary thyroid carcinoma and pheochromocytoma.

AB - The multiple endocrine neoplasia (MEN) syndromes are autosomally dominant inherited disorders in which hyperplastic or neoplastic changes occur in a wide variety of tissues. The specific syndromes are classified according to the endocrine glands affected. MEN type I consists of an aggregation of tumors of parathyroid, pancreatic, and pituitary glands. The association of medullary carcinoma of the thyroid (MCT) and pheochromocytoma is called MEN type II or type IIA, and if combined with mucosal neuromas, intestinal ganglioneuromatosis, and prominent corneal nerves, is named MEN type III or type IIB. Individuals afflicted with MEN type III are characterized by a marfanoid habitus, mucosal neuromas involving oral and ocular tissues, and a number of ophthalmologic findings including prominent corneal nerves, thickened eyelids, and subconjunctival neuromas. These features are easily recognized during the ocular exam, allowing the ophthalmologist to make an early diagnosis of this syndrome prior to the onset of life-threatening manifestations like medullary thyroid carcinoma and pheochromocytoma.

UR - http://www.scopus.com/inward/record.url?scp=0026046608&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026046608&partnerID=8YFLogxK

M3 - Article

C2 - 1682109

AN - SCOPUS:0026046608

VL - 10

SP - 454

EP - 459

JO - Cornea

JF - Cornea

SN - 0277-3740

IS - 5

ER -