Multimodal surgical adjuvant therapy for a broad spectrum of tumors in humans

G. J. Hill, R. O. Johnson, G. Metter, W. L. Wilson, H. L. Davis, T. Grage, W. S. Fletcher, F. M. Golomb, A. B. Cruz

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Co operative investigation of clinical therapy for cancer is used to test hypotheses developed in single institutions and in animal research laboratories. The present studies in a large co operative organization, the Central Oncology Group, are being conducted in seven major tumors in adults; in these studies patients with a poor surgical prognosis are being treated with preoperative or postoperative chemotherapy, preoperative radiation therapy or combinations of these modalities. Results of studies currently underway or recently completed in 1,278 patients are summarized. In most instances, the research has demonstrated little or no apparent improvement in the disease free interval or the survival time from adjuvant therapy, although only one of the studies has been completed and fully evaluated thus far. In carcinoma of the colon and rectum and melanoma, mild toxicity from drug therapy has been associated with statistically significant improvement in survival times. These studies have produced base line information on disease free intervals, time to progression and survival time in patients with cancer who are seen in the participating institutions. These observations are expected to be useful in the planning of future adjuvant studies.

Original languageEnglish (US)
Pages (from-to)882-892
Number of pages11
JournalSurgery Gynecology and Obstetrics
Issue number6
StatePublished - 1976
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Obstetrics and Gynecology


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