TY - JOUR
T1 - Multimodal randomized functional MR imaging of the effects of methylene blue in the human brain
AU - Rodriguez, Pavel
AU - Zhou, Wei
AU - Barrett, Douglas W.
AU - Altmeyer, Wilson
AU - Gutierrez, Juan E.
AU - Li, Jinqi
AU - Lancaster, Jack L.
AU - Gonzalez-Lima, Francisco
AU - Duong, Timothy Q.
N1 - Publisher Copyright:
© RSNA, 2016.
PY - 2016
Y1 - 2016
N2 - Purpose: To investigate the sustained-attention and memory-enhancing neural correlates of the oral administration of methylene blue in the healthy human brain. Materials and Methods: The institutional review board approved this prospective, HIPAA-compliant, randomized, double-blinded, placebocontrolled clinical trial, and all patients provided informed consent. Twenty-six subjects (age range, 22-62 years) were enrolled. Functional magnetic resonance (MR) imaging was performed with a psychomotor vigilance task (sustained attention) and delayed match-to-sample tasks (short-term memory) before and 1 hour after administration of low-dose methylene blue or a placebo. Cerebrovascular reactivity effects were also measured with the carbon dioxide challenge, in which a 2 × 2 repeatedmeasures analysis of variance was performed with a drug (methylene blue vs placebo) and time (before vs after administration of the drug) as factors to assess drug × time between group interactions. Multiple comparison correction was applied, with cluster-corrected P<.05 indicating a significant difference. Results: Administration of methylene blue increased response in the bilateral insular cortex during a psychomotor vigilance task (Z = 2.9-3.4, P = .01-.008) and functional MR imaging response during a short-term memory task involving the prefrontal, parietal, and occipital cortex (Z = 2.9-4.2, P = .03-.0003). Methylene blue was also associated with a 7% increase in correct responses during memory retrieval (P = .01). Conclusion: Low-dose methylene blue can increase functional MR imaging activity during sustained attention and short-term memory tasks and enhance memory retrieval.
AB - Purpose: To investigate the sustained-attention and memory-enhancing neural correlates of the oral administration of methylene blue in the healthy human brain. Materials and Methods: The institutional review board approved this prospective, HIPAA-compliant, randomized, double-blinded, placebocontrolled clinical trial, and all patients provided informed consent. Twenty-six subjects (age range, 22-62 years) were enrolled. Functional magnetic resonance (MR) imaging was performed with a psychomotor vigilance task (sustained attention) and delayed match-to-sample tasks (short-term memory) before and 1 hour after administration of low-dose methylene blue or a placebo. Cerebrovascular reactivity effects were also measured with the carbon dioxide challenge, in which a 2 × 2 repeatedmeasures analysis of variance was performed with a drug (methylene blue vs placebo) and time (before vs after administration of the drug) as factors to assess drug × time between group interactions. Multiple comparison correction was applied, with cluster-corrected P<.05 indicating a significant difference. Results: Administration of methylene blue increased response in the bilateral insular cortex during a psychomotor vigilance task (Z = 2.9-3.4, P = .01-.008) and functional MR imaging response during a short-term memory task involving the prefrontal, parietal, and occipital cortex (Z = 2.9-4.2, P = .03-.0003). Methylene blue was also associated with a 7% increase in correct responses during memory retrieval (P = .01). Conclusion: Low-dose methylene blue can increase functional MR imaging activity during sustained attention and short-term memory tasks and enhance memory retrieval.
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U2 - 10.1148/radiol.2016152893
DO - 10.1148/radiol.2016152893
M3 - Review article
C2 - 27351678
AN - SCOPUS:84992092232
SN - 0033-8419
VL - 281
SP - 516
EP - 526
JO - Radiology
JF - Radiology
IS - 2
ER -