Multimodal MRI neuroimaging biomarkers for cognitive normal adults, amnestic mild cognitive impairment, and Alzheimer's disease

Ai Ling Lin, Angela R. Laird, Peter T. Fox, Jia Hong Gao

Research output: Contribution to journalReview article

22 Scopus citations

Abstract

Multimodal magnetic resonance imaging (MRI) techniques have been developed to noninvasively measure structural, metabolic, hemodynamic and functional changes of the brain. These advantages have made MRI an important tool to investigate neurodegenerative disorders, including diagnosis, disease progression monitoring, and treatment efficacy evaluation. This paper discusses recent findings of the multimodal MRI in the context of surrogate biomarkers for identifying the risk for AD in normal cognitive (NC) adults, brain anatomical and functional alterations in amnestic mild cognitive impairment (aMCI), and Alzheimer's disease (AD) patients. Further developments of these techniques and the establishment of promising neuroimaging biomarkers will enhance our ability to diagnose aMCI and AD in their early stages and improve the assessment of therapeutic efficacy in these diseases in future clinical trials.

Original languageEnglish (US)
Article number907409
JournalNeurology Research International
Volume2012
DOIs
StatePublished - Sep 18 2012

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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