@article{709ec3730df34bb9a0028fa89509c127,
title = "Multimodal and Multiscale Deep Neural Networks for the Early Diagnosis of Alzheimer{\textquoteright}s Disease using structural MR and FDG-PET images",
abstract = "Alzheimer{\textquoteright}s Disease (AD) is a progressive neurodegenerative disease where biomarkers for disease based on pathophysiology may be able to provide objective measures for disease diagnosis and staging. Neuroimaging scans acquired from MRI and metabolism images obtained by FDG-PET provide in-vivo measurements of structure and function (glucose metabolism) in a living brain. It is hypothesized that combining multiple different image modalities providing complementary information could help improve early diagnosis of AD. In this paper, we propose a novel deep-learning-based framework to discriminate individuals with AD utilizing a multimodal and multiscale deep neural network. Our method delivers 82.4% accuracy in identifying the individuals with mild cognitive impairment (MCI) who will convert to AD at 3 years prior to conversion (86.4% combined accuracy for conversion within 1–3 years), a 94.23% sensitivity in classifying individuals with clinical diagnosis of probable AD, and a 86.3% specificity in classifying non-demented controls improving upon results in published literature.",
author = "{Alzheimer's Disease Neuroimaging Initiative} and Donghuan Lu and Karteek Popuri and Ding, {Gavin Weiguang} and Rakesh Balachandar and Beg, {Mirza Faisal} and Michael Weiner and Paul Aisen and Ronald Petersen and Cliford Jack and William Jagust and John Trojanowki and Arthur Toga and Laurel Beckett and Robert Green and Andrew Saykin and Morris, {John C.} and Leslie Shaw and Jefrey Kaye and Joseph Quinn and Lisa Silbert and Betty Lind and Raina Carter and Sara Dolen and Lon Schneider and Sonia Pawluczyk and Mauricio Beccera and Liberty Teodoro and Bryan Spann and James Brewer and Helen Vanderswag and Adam Fleisher and Judith Heidebrink and Joanne Lord and Sara Mason and Colleen Albers and David Knopman and Kris Johnson and Rachelle Doody and Javier Villanueva-Meyer and Munir Chowdhury and Susan Rountree and Mimi Dang and Yaakov Stern and Lawrence Honig and Karen Bell and Beau Ances and Maria Carroll and Mary Creech and Erin Franklin and Brittany Cerbone",
note = "Publisher Copyright: {\textcopyright} 2018, The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41598-018-22871-z",
language = "English (US)",
volume = "8",
journal = "Scientific reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}