Multidimensional Approach Assessing the Role of Interleukin 1 Beta in Mesial Temporal Lobe Epilepsy

Renato O. Santos, Rodrigo Secolin, Patrícia G. Barbalho, Mariana S. Silva-Alves, Marina K.M. Alvim, Clarissa L. Yasuda, Fábio Rogerio, Tonicarlo R. Velasco, Americo C. Sakamoto, Antonio L. Teixeira, Fernando Cendes, Claudia V. Maurer-Morelli, Iscia Lopes-Cendes

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


We aimed to investigate the role of interleukin-1 beta (IL-1β) in the mechanisms underlying mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE+HS). We assessed a cohort of 194 patients with MTLE+HS and 199 healthy controls. Patients were divided into those with positive and negative antecedent febrile seizures (FS). We used a multidimensional approach, including (i) genetic association with single nucleotide polymorphisms (SNPs) in the IL1B gene; (ii) quantification of the IL1B transcript in the hippocampal tissue of patients with refractory seizures; and (iii) quantification of the IL-1β protein in the plasma. We found a genetic association signal for two SNPs, rs2708928 and rs3730364*C in the IL1B gene, regardless of the presence of FS (adjusted p = 9.62e–11 and 5.14e–07, respectively). We found no difference between IL1B transcript levels when comparing sclerotic hippocampal tissue from patients with MTLE+HS, without FS, and hippocampi from autopsy controls (p > 0.05). Nevertheless, we found increased IL-1β in the plasma of patients with MTLE+HS with FS compared with controls (p = 0.0195). Our results support the hypothesis of a genetic association between MTLE+HS and the IL1B gene.

Original languageEnglish (US)
Article number690847
JournalFrontiers in Neurology
StatePublished - Aug 5 2021
Externally publishedYes


  • association study
  • gene expression
  • hippocampal atrophy
  • mesial temporal sclerosis
  • neuroinflammation

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


Dive into the research topics of 'Multidimensional Approach Assessing the Role of Interleukin 1 Beta in Mesial Temporal Lobe Epilepsy'. Together they form a unique fingerprint.

Cite this