Multicenter Comparison of Emergency Release Group A versus AB Plasma in Blunt-Injured Trauma Patients

Martin D. Zielinski, Jason J. Schrager, Pamela Johnson, James R. Stubbs, Stephanie Polites, Scott P. Zietlow, Donald H. Jenkins, Bryce R.H. Robinson

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Introduction: Group AB plasma, the traditional universal donor plasma product, is a limited resource. We compared outcomes of Group A plasma transfusion in comparison to AB. Methods: Analysis of blunt-injured patients who received emergency release plasma from was performed. Multivariable logistic regression was utilized to identify associations with morbidity and mortality. Results: There were 191 patients; 115 Group A and 76 Group AB. No differences were seen in age, sex, plasma transfusions, uncrossmatched red blood cells (RBCs), and Glasgow Coma Scale (GCS). Patients who received Group A plasma had significantly lower Injury Severity Score, chest Abbreviated Injury Scale (AIS), and scene transfer rate but not head AIS, or abdomen AIS. In addition, significant differences were noted in terms of blood products transfused within 24 hours in those receiving Group A over AB. Development of acute respiratory distress syndrome (ARDS), but not mortality, was higher within the AB cohort. No hemolytic or transfusion associated-ARDS reactions were noted in either group. ARDS; RBC transfusion volumes and head AIS were independently associated with mortality. Conclusion: Utilization of Group A plasma for emergency blood resuscitation is a safe option which may alleviate potential shortages of AB plasma.

Original languageEnglish (US)
Pages (from-to)43-47
Number of pages5
JournalClinical and translational science
Issue number1
StatePublished - Feb 1 2015
Externally publishedYes


  • Hemorrhage
  • Massive transfusion
  • Plasma
  • Resuscitation
  • Trauma

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience


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