Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, MEGAST ROKE Consortium, AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STA RNET BioBank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium (ISGC), METAST ROKE Consortium

Research output: Contribution to journalArticle

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Abstract

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and discovered 22 new stroke risk loci, bringing the total to 32. We further found shared genetic variation with related vascular traits, including blood pressure, cardiac traits, and venous thromboembolism, at individual loci (n = 18), and using genetic risk scores and linkage-disequilibrium-score regression. Several loci exhibited distinct association and pleiotropy patterns for etiological stroke subtypes. Eleven new susceptibility loci indicate mechanisms not previously implicated in stroke pathophysiology, with prioritization of risk variants and genes accomplished through bioinformatics analyses using extensive functional datasets. Stroke risk loci were significantly enriched in drug targets for antithrombotic therapy.

Original languageEnglish (US)
Pages (from-to)524-537
Number of pages14
JournalNature Genetics
Volume50
Issue number4
DOIs
StatePublished - Apr 1 2018

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Genome-Wide Association Study
Stroke
Venous Thromboembolism
Linkage Disequilibrium
Computational Biology
Genes
Blood Vessels
Meta-Analysis
Blood Pressure
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Genetics

Cite this

Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, MEGAST ROKE Consortium, AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, ... METAST ROKE Consortium (2018). Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics, 50(4), 524-537. https://doi.org/10.1038/s41588-018-0058-3

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. / Neurology Working Group of the CHARGE Consortium; NINDS Stroke Genetics Network (SiGN); UK Young Lacunar DNA Study; MEGAST ROKE Consortium; AFGen Consortium; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; International Genomics of Blood Pressure (iGEN-BP) Consortium; INVENT Consortium; STA RNET BioBank Japan Cooperative Hospital Group; COMPASS Consortium; EPIC-CVD Consortium; EPIC-InterAct Consortium; International Stroke Genetics Consortium (ISGC); METAST ROKE Consortium.

In: Nature Genetics, Vol. 50, No. 4, 01.04.2018, p. 524-537.

Research output: Contribution to journalArticle

Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, MEGAST ROKE Consortium, AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Genomics of Blood Pressure (iGEN-BP) Consortium, INVENT Consortium, STA RNET BioBank Japan Cooperative Hospital Group, COMPASS Consortium, EPIC-CVD Consortium, EPIC-InterAct Consortium, International Stroke Genetics Consortium (ISGC) & METAST ROKE Consortium 2018, 'Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes', Nature Genetics, vol. 50, no. 4, pp. 524-537. https://doi.org/10.1038/s41588-018-0058-3
Neurology Working Group of the CHARGE Consortium, NINDS Stroke Genetics Network (SiGN), UK Young Lacunar DNA Study, MEGAST ROKE Consortium, AFGen Consortium, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium et al. Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. Nature Genetics. 2018 Apr 1;50(4):524-537. https://doi.org/10.1038/s41588-018-0058-3
Neurology Working Group of the CHARGE Consortium ; NINDS Stroke Genetics Network (SiGN) ; UK Young Lacunar DNA Study ; MEGAST ROKE Consortium ; AFGen Consortium ; Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium ; International Genomics of Blood Pressure (iGEN-BP) Consortium ; INVENT Consortium ; STA RNET BioBank Japan Cooperative Hospital Group ; COMPASS Consortium ; EPIC-CVD Consortium ; EPIC-InterAct Consortium ; International Stroke Genetics Consortium (ISGC) ; METAST ROKE Consortium. / Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. In: Nature Genetics. 2018 ; Vol. 50, No. 4. pp. 524-537.
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AU - AFGen Consortium

AU - Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium

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