MTOR signaling in aging and aging-associated diseases

Jie Yu He, Feng Liu

Research output: Contribution to journalReview article

1 Scopus citations


Aging causes a general decline in physiological function that leads to various metabolic and cardiovascular diseases. The links between aging and aging-associated diseases remain to be fully established, but recent studies demonstrate that suppressing the mammalian/mechanistic target of rapamycin (mTOR) signaling pathway extends longevity and delays aging-associated metabolic and neurodegenerative diseases. As a key regulator of metabolism and aging, the mTOR signaling pathway has now become a hot spot for the development of effective therapeutic treatment for aging and aging-related diseases.

Original languageEnglish (US)
Pages (from-to)257-265
Number of pages9
JournalProgress in Biochemistry and Biophysics
Issue number3
Publication statusPublished - Mar 2014



  • Aging
  • Aging-related diseases
  • Autophagy
  • ER stress
  • MTOR

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry

Cite this