Abstract
Aging causes a general decline in physiological function that leads to various metabolic and cardiovascular diseases. The links between aging and aging-associated diseases remain to be fully established, but recent studies demonstrate that suppressing the mammalian/mechanistic target of rapamycin (mTOR) signaling pathway extends longevity and delays aging-associated metabolic and neurodegenerative diseases. As a key regulator of metabolism and aging, the mTOR signaling pathway has now become a hot spot for the development of effective therapeutic treatment for aging and aging-related diseases.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 257-265 |
| Number of pages | 9 |
| Journal | Progress in Biochemistry and Biophysics |
| Volume | 41 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 2014 |
| Externally published | Yes |
Keywords
- Aging
- Aging-related diseases
- Autophagy
- ER stress
- MTOR
ASJC Scopus subject areas
- Biophysics
- Biochemistry