Aging causes a general decline in physiological function that leads to various metabolic and cardiovascular diseases. The links between aging and aging-associated diseases remain to be fully established, but recent studies demonstrate that suppressing the mammalian/mechanistic target of rapamycin (mTOR) signaling pathway extends longevity and delays aging-associated metabolic and neurodegenerative diseases. As a key regulator of metabolism and aging, the mTOR signaling pathway has now become a hot spot for the development of effective therapeutic treatment for aging and aging-related diseases.
|Original language||English (US)|
|Number of pages||9|
|Journal||Progress in Biochemistry and Biophysics|
|State||Published - Mar 2014|
- Aging-related diseases
- ER stress
ASJC Scopus subject areas