MTOR coordinates protein synthesis, mitochondrial activity

Masahiro Morita, Simon Pierre Gravel, Laura Hulea, Ola Larsson, Michael Pollak, Julie St-Pierre, Ivan Topisirovic

Research output: Contribution to journalReview articlepeer-review

165 Scopus citations

Abstract

Protein synthesis is one of the most energy consuming processes in the cell. The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that integrates a multitude of extracellular signals and intracellular cues to drive growth and proliferation. mTOR activity is altered in numerous pathological conditions, including metabolic syndrome and cancer. In addition to its well-established role in regulating mRNA translation, emerging studies indicate that mTOR modulates mitochondrial functions. In mammals, mTOR coordinates energy consumption by the mRNA translation machinery and mitochondrial energy production by stimulating synthesis of nucleus-encoded mitochondria-related proteins including TFAM, mitochondrial ribosomal proteins and components of complexes I and V. In this review, we highlight findings that link mTOR, mRNA translation and mitochondrial functions.

Original languageEnglish (US)
Pages (from-to)473-480
Number of pages8
JournalCell Cycle
Volume14
Issue number4
DOIs
StatePublished - Feb 15 2015

Keywords

  • 4E-BP1
  • EIF4E
  • MRNA translation
  • MTOR
  • Metabolism
  • Mitochondria
  • Oxidative phosphorylation
  • Tca cycle

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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