MTOR coordinates protein synthesis, mitochondrial activity

Masahiro Morita, Simon Pierre Gravel, Laura Hulea, Ola Larsson, Michael Pollak, Julie St-Pierre, Ivan Topisirovic

Research output: Contribution to journalReview article

105 Citations (Scopus)

Abstract

Protein synthesis is one of the most energy consuming processes in the cell. The mammalian/mechanistic target of rapamycin (mTOR) is a serine/threonine kinase that integrates a multitude of extracellular signals and intracellular cues to drive growth and proliferation. mTOR activity is altered in numerous pathological conditions, including metabolic syndrome and cancer. In addition to its well-established role in regulating mRNA translation, emerging studies indicate that mTOR modulates mitochondrial functions. In mammals, mTOR coordinates energy consumption by the mRNA translation machinery and mitochondrial energy production by stimulating synthesis of nucleus-encoded mitochondria-related proteins including TFAM, mitochondrial ribosomal proteins and components of complexes I and V. In this review, we highlight findings that link mTOR, mRNA translation and mitochondrial functions.

Original languageEnglish (US)
Pages (from-to)473-480
Number of pages8
JournalCell Cycle
Volume14
Issue number4
DOIs
StatePublished - Feb 15 2015
Externally publishedYes

Fingerprint

Mitochondrial Proteins
Sirolimus
Protein Biosynthesis
Ribosomal Proteins
Protein-Serine-Threonine Kinases
Cues
Mammals
Mitochondria
Proteins
Growth
Neoplasms

Keywords

  • 4E-BP1
  • EIF4E
  • Metabolism
  • Mitochondria
  • MRNA translation
  • MTOR
  • Oxidative phosphorylation
  • Tca cycle

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

Cite this

Morita, M., Gravel, S. P., Hulea, L., Larsson, O., Pollak, M., St-Pierre, J., & Topisirovic, I. (2015). MTOR coordinates protein synthesis, mitochondrial activity. Cell Cycle, 14(4), 473-480. https://doi.org/10.4161/15384101.2014.991572

MTOR coordinates protein synthesis, mitochondrial activity. / Morita, Masahiro; Gravel, Simon Pierre; Hulea, Laura; Larsson, Ola; Pollak, Michael; St-Pierre, Julie; Topisirovic, Ivan.

In: Cell Cycle, Vol. 14, No. 4, 15.02.2015, p. 473-480.

Research output: Contribution to journalReview article

Morita, M, Gravel, SP, Hulea, L, Larsson, O, Pollak, M, St-Pierre, J & Topisirovic, I 2015, 'MTOR coordinates protein synthesis, mitochondrial activity', Cell Cycle, vol. 14, no. 4, pp. 473-480. https://doi.org/10.4161/15384101.2014.991572
Morita M, Gravel SP, Hulea L, Larsson O, Pollak M, St-Pierre J et al. MTOR coordinates protein synthesis, mitochondrial activity. Cell Cycle. 2015 Feb 15;14(4):473-480. https://doi.org/10.4161/15384101.2014.991572
Morita, Masahiro ; Gravel, Simon Pierre ; Hulea, Laura ; Larsson, Ola ; Pollak, Michael ; St-Pierre, Julie ; Topisirovic, Ivan. / MTOR coordinates protein synthesis, mitochondrial activity. In: Cell Cycle. 2015 ; Vol. 14, No. 4. pp. 473-480.
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