mTOR as a target for cancer therapy

P. J. Houghton, S. Huang

Research output: Contribution to journalReview articlepeer-review

65 Scopus citations


The target of rapamycin, mTOR, acts as a sensor for mitogenic stimuli, such as insulin-like growth factors and cellular nutritional status, regulating cellular growth and division. As many tumors are driven by autocrine or paracrine growth through the type-I insulin-like growth factor receptor, mTOR is potentially an attractive target for molecular-targeted treatment. Further, a rationale for anticipating tumor-selective activity based on transforming events frequently identified in malignant disease is becoming established.

Original languageEnglish (US)
Pages (from-to)339-359
Number of pages21
JournalCurrent topics in microbiology and immunology
StatePublished - 2003
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)


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