MRX8: An X-linked mental retardation condition with linkage to Xq21

C. E. Schwartz, M. May, Hui-ming Huang, D. Ledbetter, G. Anderson, D. F. Barker, H. A. Lubs, F. Arena, R. E. Stevenson

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A family in which 6 males have X-linked mental retardation has been studied with polymorphic DNA probes. The males differ from unaffected males only in impaired intellect and in smaller head size. The gene that causes mental retardation in the family appears to be located in band Xq21 on the basis of linkage with 3 markers: DXS250, DXS345 and DXS3 (θmax = 0.00; Zmax = 1.6). A multipoint lod score of 2.36 was obtain with no recombination relative to DXS326 in Xq21. This family is considered to have nonspecific X- linked mental retardation and has been given the designation MRX8.

Original languageEnglish (US)
Pages (from-to)467-474
Number of pages8
JournalAmerican Journal of Medical Genetics
Volume43
Issue number1-2
DOIs
StatePublished - 1992
Externally publishedYes

Fingerprint

X-Linked Mental Retardation
Lod Score
DNA Probes
Intellectual Disability
Genetic Recombination
Head
Genes

Keywords

  • Mental retardation
  • nonspecific mental retardation
  • X-linked recessive

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Schwartz, C. E., May, M., Huang, H., Ledbetter, D., Anderson, G., Barker, D. F., ... Stevenson, R. E. (1992). MRX8: An X-linked mental retardation condition with linkage to Xq21. American Journal of Medical Genetics, 43(1-2), 467-474. https://doi.org/10.1002/ajmg.1320430170

MRX8 : An X-linked mental retardation condition with linkage to Xq21. / Schwartz, C. E.; May, M.; Huang, Hui-ming; Ledbetter, D.; Anderson, G.; Barker, D. F.; Lubs, H. A.; Arena, F.; Stevenson, R. E.

In: American Journal of Medical Genetics, Vol. 43, No. 1-2, 1992, p. 467-474.

Research output: Contribution to journalArticle

Schwartz, CE, May, M, Huang, H, Ledbetter, D, Anderson, G, Barker, DF, Lubs, HA, Arena, F & Stevenson, RE 1992, 'MRX8: An X-linked mental retardation condition with linkage to Xq21', American Journal of Medical Genetics, vol. 43, no. 1-2, pp. 467-474. https://doi.org/10.1002/ajmg.1320430170
Schwartz, C. E. ; May, M. ; Huang, Hui-ming ; Ledbetter, D. ; Anderson, G. ; Barker, D. F. ; Lubs, H. A. ; Arena, F. ; Stevenson, R. E. / MRX8 : An X-linked mental retardation condition with linkage to Xq21. In: American Journal of Medical Genetics. 1992 ; Vol. 43, No. 1-2. pp. 467-474.
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