MRX8: An X-linked mental retardation condition with linkage to Xq21

C. E. Schwartz; M. May; T. Huang; D. Ledbetter; G. Anderson; D. F. Barker; H. A. Lubs; F. Arena; R. E. Stevenson

doi:10.1002/ajmg.1320430170

MRX8: An X-linked mental retardation condition with linkage to Xq21

C. E. Schwartz, M. May, T. Huang, D. Ledbetter, G. Anderson, D. F. Barker, H. A. Lubs, F. Arena, R. E. Stevenson

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A family in which 6 males have X-linked mental retardation has been studied with polymorphic DNA probes. The males differ from unaffected males only in impaired intellect and in smaller head size. The gene that causes mental retardation in the family appears to be located in band Xq21 on the basis of linkage with 3 markers: DXS250, DXS345 and DXS3 (θmax = 0.00; Zmax = 1.6). A multipoint lod score of 2.36 was obtain with no recombination relative to DXS326 in Xq21. This family is considered to have nonspecific X- linked mental retardation and has been given the designation MRX8.

Original language	English (US)
Pages (from-to)	467-474
Number of pages	8
Journal	American Journal of Medical Genetics
Volume	43
Issue number	1-2
DOIs	https://doi.org/10.1002/ajmg.1320430170
State	Published - 1992
Externally published	Yes

Keywords

Mental retardation
X-linked recessive
nonspecific mental retardation

ASJC Scopus subject areas

Genetics(clinical)
Genetics

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abstract = "A family in which 6 males have X-linked mental retardation has been studied with polymorphic DNA probes. The males differ from unaffected males only in impaired intellect and in smaller head size. The gene that causes mental retardation in the family appears to be located in band Xq21 on the basis of linkage with 3 markers: DXS250, DXS345 and DXS3 (θmax = 0.00; Zmax = 1.6). A multipoint lod score of 2.36 was obtain with no recombination relative to DXS326 in Xq21. This family is considered to have nonspecific X- linked mental retardation and has been given the designation MRX8.",

keywords = "Mental retardation, X-linked recessive, nonspecific mental retardation",

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T2 - An X-linked mental retardation condition with linkage to Xq21

AU - Schwartz, C. E.

AU - May, M.

AU - Huang, T.

AU - Ledbetter, D.

AU - Anderson, G.

AU - Barker, D. F.

AU - Lubs, H. A.

AU - Arena, F.

AU - Stevenson, R. E.

PY - 1992

Y1 - 1992

N2 - A family in which 6 males have X-linked mental retardation has been studied with polymorphic DNA probes. The males differ from unaffected males only in impaired intellect and in smaller head size. The gene that causes mental retardation in the family appears to be located in band Xq21 on the basis of linkage with 3 markers: DXS250, DXS345 and DXS3 (θmax = 0.00; Zmax = 1.6). A multipoint lod score of 2.36 was obtain with no recombination relative to DXS326 in Xq21. This family is considered to have nonspecific X- linked mental retardation and has been given the designation MRX8.

AB - A family in which 6 males have X-linked mental retardation has been studied with polymorphic DNA probes. The males differ from unaffected males only in impaired intellect and in smaller head size. The gene that causes mental retardation in the family appears to be located in band Xq21 on the basis of linkage with 3 markers: DXS250, DXS345 and DXS3 (θmax = 0.00; Zmax = 1.6). A multipoint lod score of 2.36 was obtain with no recombination relative to DXS326 in Xq21. This family is considered to have nonspecific X- linked mental retardation and has been given the designation MRX8.

KW - Mental retardation

KW - X-linked recessive

KW - nonspecific mental retardation

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MRX8: An X-linked mental retardation condition with linkage to Xq21

Abstract

Keywords

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