MRI in experimental stroke

Timothy Q. Duong

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Stroke is the third leading cause of death and the leading cause of long-term disability in the United States. Brain imaging data from experimental stroke models and stroke patients have shown that there is often a gradual progression of potentially reversible ischemic injury toward infarction. A central core with severely compromised cerebral blood flow (CBF) is surrounded by a rim of moderately ischemic tissue with diminished CBF and impaired electrical activity but preserved cellular metabolism, often referred to as the "ischemic penumbra." Re-establishing tissue perfusion and/or treating with neuroprotective drugs in a timely fashion is expected to salvage some ischemic tissues. Diffusion-weighted imaging (DWI) based on magnetic resonance imaging (MRI) in which contrast is based on water apparent diffusion coefficient (ADC) can detect ischemic injury within minutes after onsets, whereas computed tomography and other imaging modalities fail to detect stroke injury for at least a few hours. Along with quantitative perfusion imaging, the perfusion-diffusion mismatch which approximates the ischemic penumbra could be defined non-invasively. This chapter describes stroke modeling, perfusion, diffusion, and some other MRI techniques commonly used to image acute stroke and, finally, image analysis pertaining to experimental stroke imaging.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages473-485
Number of pages13
Volume711
DOIs
StatePublished - 2010

Publication series

NameMethods in Molecular Biology
Volume711
ISSN (Print)10643745

Fingerprint

Stroke
Magnetic Resonance Imaging
Cerebrovascular Circulation
Perfusion
Wounds and Injuries
Perfusion Imaging
Neuroprotective Agents
Neuroimaging
Infarction
Cause of Death
Theoretical Models
Tomography
Water

Keywords

  • ADC
  • CBF
  • DWI
  • experimental stroke model
  • fMRI
  • MRI
  • perfusion-diffusion mismatch
  • PWI
  • rodents

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Medicine(all)

Cite this

Duong, T. Q. (2010). MRI in experimental stroke. In Methods in Molecular Biology (Vol. 711, pp. 473-485). (Methods in Molecular Biology; Vol. 711). https://doi.org/10.1007/978-1-61737-992-5_24

MRI in experimental stroke. / Duong, Timothy Q.

Methods in Molecular Biology. Vol. 711 2010. p. 473-485 (Methods in Molecular Biology; Vol. 711).

Research output: Chapter in Book/Report/Conference proceedingChapter

Duong, TQ 2010, MRI in experimental stroke. in Methods in Molecular Biology. vol. 711, Methods in Molecular Biology, vol. 711, pp. 473-485. https://doi.org/10.1007/978-1-61737-992-5_24
Duong TQ. MRI in experimental stroke. In Methods in Molecular Biology. Vol. 711. 2010. p. 473-485. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-61737-992-5_24
Duong, Timothy Q. / MRI in experimental stroke. Methods in Molecular Biology. Vol. 711 2010. pp. 473-485 (Methods in Molecular Biology).
@inbook{d0cdc41241804bada3000bed2ed872e4,
title = "MRI in experimental stroke",
abstract = "Stroke is the third leading cause of death and the leading cause of long-term disability in the United States. Brain imaging data from experimental stroke models and stroke patients have shown that there is often a gradual progression of potentially reversible ischemic injury toward infarction. A central core with severely compromised cerebral blood flow (CBF) is surrounded by a rim of moderately ischemic tissue with diminished CBF and impaired electrical activity but preserved cellular metabolism, often referred to as the {"}ischemic penumbra.{"} Re-establishing tissue perfusion and/or treating with neuroprotective drugs in a timely fashion is expected to salvage some ischemic tissues. Diffusion-weighted imaging (DWI) based on magnetic resonance imaging (MRI) in which contrast is based on water apparent diffusion coefficient (ADC) can detect ischemic injury within minutes after onsets, whereas computed tomography and other imaging modalities fail to detect stroke injury for at least a few hours. Along with quantitative perfusion imaging, the perfusion-diffusion mismatch which approximates the ischemic penumbra could be defined non-invasively. This chapter describes stroke modeling, perfusion, diffusion, and some other MRI techniques commonly used to image acute stroke and, finally, image analysis pertaining to experimental stroke imaging.",
keywords = "ADC, CBF, DWI, experimental stroke model, fMRI, MRI, perfusion-diffusion mismatch, PWI, rodents",
author = "Duong, {Timothy Q.}",
year = "2010",
doi = "10.1007/978-1-61737-992-5_24",
language = "English (US)",
isbn = "9781617379918",
volume = "711",
series = "Methods in Molecular Biology",
pages = "473--485",
booktitle = "Methods in Molecular Biology",

}

TY - CHAP

T1 - MRI in experimental stroke

AU - Duong, Timothy Q.

PY - 2010

Y1 - 2010

N2 - Stroke is the third leading cause of death and the leading cause of long-term disability in the United States. Brain imaging data from experimental stroke models and stroke patients have shown that there is often a gradual progression of potentially reversible ischemic injury toward infarction. A central core with severely compromised cerebral blood flow (CBF) is surrounded by a rim of moderately ischemic tissue with diminished CBF and impaired electrical activity but preserved cellular metabolism, often referred to as the "ischemic penumbra." Re-establishing tissue perfusion and/or treating with neuroprotective drugs in a timely fashion is expected to salvage some ischemic tissues. Diffusion-weighted imaging (DWI) based on magnetic resonance imaging (MRI) in which contrast is based on water apparent diffusion coefficient (ADC) can detect ischemic injury within minutes after onsets, whereas computed tomography and other imaging modalities fail to detect stroke injury for at least a few hours. Along with quantitative perfusion imaging, the perfusion-diffusion mismatch which approximates the ischemic penumbra could be defined non-invasively. This chapter describes stroke modeling, perfusion, diffusion, and some other MRI techniques commonly used to image acute stroke and, finally, image analysis pertaining to experimental stroke imaging.

AB - Stroke is the third leading cause of death and the leading cause of long-term disability in the United States. Brain imaging data from experimental stroke models and stroke patients have shown that there is often a gradual progression of potentially reversible ischemic injury toward infarction. A central core with severely compromised cerebral blood flow (CBF) is surrounded by a rim of moderately ischemic tissue with diminished CBF and impaired electrical activity but preserved cellular metabolism, often referred to as the "ischemic penumbra." Re-establishing tissue perfusion and/or treating with neuroprotective drugs in a timely fashion is expected to salvage some ischemic tissues. Diffusion-weighted imaging (DWI) based on magnetic resonance imaging (MRI) in which contrast is based on water apparent diffusion coefficient (ADC) can detect ischemic injury within minutes after onsets, whereas computed tomography and other imaging modalities fail to detect stroke injury for at least a few hours. Along with quantitative perfusion imaging, the perfusion-diffusion mismatch which approximates the ischemic penumbra could be defined non-invasively. This chapter describes stroke modeling, perfusion, diffusion, and some other MRI techniques commonly used to image acute stroke and, finally, image analysis pertaining to experimental stroke imaging.

KW - ADC

KW - CBF

KW - DWI

KW - experimental stroke model

KW - fMRI

KW - MRI

KW - perfusion-diffusion mismatch

KW - PWI

KW - rodents

UR - http://www.scopus.com/inward/record.url?scp=79955675105&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955675105&partnerID=8YFLogxK

U2 - 10.1007/978-1-61737-992-5_24

DO - 10.1007/978-1-61737-992-5_24

M3 - Chapter

C2 - 21279618

AN - SCOPUS:79955675105

SN - 9781617379918

VL - 711

T3 - Methods in Molecular Biology

SP - 473

EP - 485

BT - Methods in Molecular Biology

ER -