MRI in experimental stroke

Timothy Q. Duong

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Stroke is the third leading cause of death and the leading cause of long-term disability in the United States. Brain imaging data from experimental stroke models and stroke patients have shown that there is often a gradual progression of potentially reversible ischemic injury toward infarction. A central core with severely compromised cerebral blood flow (CBF) is surrounded by a rim of moderately ischemic tissue with diminished CBF and impaired electrical activity but preserved cellular metabolism, often referred to as the "ischemic penumbra." Re-establishing tissue perfusion and/or treating with neuroprotective drugs in a timely fashion is expected to salvage some ischemic tissues. Diffusion-weighted imaging (DWI) based on magnetic resonance imaging (MRI) in which contrast is based on water apparent diffusion coefficient (ADC) can detect ischemic injury within minutes after onsets, whereas computed tomography and other imaging modalities fail to detect stroke injury for at least a few hours. Along with quantitative perfusion imaging, the perfusion-diffusion mismatch which approximates the ischemic penumbra could be defined non-invasively. This chapter describes stroke modeling, perfusion, diffusion, and some other MRI techniques commonly used to image acute stroke and, finally, image analysis pertaining to experimental stroke imaging.

Original languageEnglish (US)
Title of host publicationMagnetic Resonance Neuroimaging
Subtitle of host publicationMethods and Protocols
EditorsMichel Modo, Jelte Bulte
Pages473-485
Number of pages13
DOIs
StatePublished - 2010

Publication series

NameMethods in Molecular Biology
Volume711
ISSN (Print)1064-3745

Keywords

  • ADC
  • CBF
  • DWI
  • MRI
  • PWI
  • experimental stroke model
  • fMRI
  • perfusion-diffusion mismatch
  • rodents

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Fingerprint Dive into the research topics of 'MRI in experimental stroke'. Together they form a unique fingerprint.

Cite this