@inproceedings{03f48aff6b624e308ebdabb7363d336d,
title = "MRI based biomarker for brain aging in rodents and non-human primates",
abstract = "This work presents two novel species-specific adaptations of a MRI based biomarker that indicates individual deviations from normal brain aging trajectories for rodents and non-human primates. By employing automatic, speciesspecific preprocessing of anatomical brain MRI as well as highdimensional pattern recognition methods, this approach uses the distribution of healthy brain-aging patterns to estimate individual brain ages. This biomarker may probably enable tracking the effects of developmental and environmental influences, manipulations, and (preventive) treatments on individual deviations from species-specific brain aging trajectories in experimental mammal models across the life-course.",
keywords = "Aging; BrainAGE, DBM, MRI, VBM, machine learning, mammals, relevance vector regression (RVR)",
author = "Katja Frankea and Robert Dahnke and Geoffrey Clarke and Anderson Kuo and Cun Li and Peter Nathanielsz and Matthias Schwab and Christian Gaser",
note = "Publisher Copyright: {\textcopyright} 2016 IEEE.; 6th International Workshop on Pattern Recognition in Neuroimaging, PRNI 2016 ; Conference date: 22-06-2016 Through 24-06-2016",
year = "2016",
month = aug,
day = "24",
doi = "10.1109/PRNI.2016.7552326",
language = "English (US)",
series = "PRNI 2016 - 6th International Workshop on Pattern Recognition in Neuroimaging",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
booktitle = "PRNI 2016 - 6th International Workshop on Pattern Recognition in Neuroimaging",
address = "United States",
}