Benz[j]aceanthrylene (B[j]A), a cyclopenta-fused derivative of benz[a]anthracene, has been reported to be an active bacterial cell and mammalian cell gene mutagen, a morphological transforming agent in C3H10T 1 2CL8 mouse embryo fibroblasts and a mouse lung tumorigen in strain A J mice. B[j]A was evaluated as a skin tumor initiator in female SENCAR mice and was found to induce papilloma formation in the range of 40-400 μg/mouse. B[j]A was found to be extremely active, inducing 8.7 papillomas/mouse after an initiating dose of 40 μg/mouse. At this dose, 100% of the mice bore tumors. Comparison with four other cyclopenta-fused polycyclic aromatic hydrocarbons suggests that B[j]A is extremely potent.
|Original language||English (US)|
|Number of pages||4|
|State||Published - Sep 30 1993|
- SENCAR mice
- Tumor initiation
ASJC Scopus subject areas
- Cancer Research