Mouse skin tumor-initiating activity of benz[j]aceanthrylene in SENCAR mice

Stephen Nesnow; Avram Gold; R. Sangaiah; Thomas J. Slaga

doi:10.1016/0304-3835(93)90247-7

Mouse skin tumor-initiating activity of benz[j]aceanthrylene in SENCAR mice

Stephen Nesnow, Avram Gold, R. Sangaiah, Thomas J. Slaga

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Benz[j]aceanthrylene (B[j]A), a cyclopenta-fused derivative of benz[a]anthracene, has been reported to be an active bacterial cell and mammalian cell gene mutagen, a morphological transforming agent in C3H10T 1 2CL8 mouse embryo fibroblasts and a mouse lung tumorigen in strain A J mice. B[j]A was evaluated as a skin tumor initiator in female SENCAR mice and was found to induce papilloma formation in the range of 40-400 μg/mouse. B[j]A was found to be extremely active, inducing 8.7 papillomas/mouse after an initiating dose of 40 μg/mouse. At this dose, 100% of the mice bore tumors. Comparison with four other cyclopenta-fused polycyclic aromatic hydrocarbons suggests that B[j]A is extremely potent.

Original language	English (US)
Pages (from-to)	73-76
Number of pages	4
Journal	Cancer Letters
Volume	73
Issue number	2-3
DOIs	https://doi.org/10.1016/0304-3835(93)90247-7
State	Published - Sep 30 1993
Externally published	Yes

Keywords

Benz[j]aceanthrylene
SENCAR mice
Tumor initiation
benzo[a]pyrene

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(93)90247-7

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@article{24334abe52944233b9565c5d24d3acfa,

title = "Mouse skin tumor-initiating activity of benz[j]aceanthrylene in SENCAR mice",

abstract = "Benz[j]aceanthrylene (B[j]A), a cyclopenta-fused derivative of benz[a]anthracene, has been reported to be an active bacterial cell and mammalian cell gene mutagen, a morphological transforming agent in C3H10T 1 2CL8 mouse embryo fibroblasts and a mouse lung tumorigen in strain A J mice. B[j]A was evaluated as a skin tumor initiator in female SENCAR mice and was found to induce papilloma formation in the range of 40-400 μg/mouse. B[j]A was found to be extremely active, inducing 8.7 papillomas/mouse after an initiating dose of 40 μg/mouse. At this dose, 100% of the mice bore tumors. Comparison with four other cyclopenta-fused polycyclic aromatic hydrocarbons suggests that B[j]A is extremely potent.",

keywords = "Benz[j]aceanthrylene, SENCAR mice, Tumor initiation, benzo[a]pyrene",

author = "Stephen Nesnow and Avram Gold and R. Sangaiah and Slaga, {Thomas J.}",

note = "Funding Information: This work was supported in part by the U.S. Public Health Service (grant no. CA47964).",

year = "1993",

month = sep,

day = "30",

doi = "10.1016/0304-3835(93)90247-7",

language = "English (US)",

volume = "73",

pages = "73--76",

journal = "Cancer Letters",

issn = "0304-3835",

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number = "2-3",

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T1 - Mouse skin tumor-initiating activity of benz[j]aceanthrylene in SENCAR mice

AU - Nesnow, Stephen

AU - Gold, Avram

AU - Sangaiah, R.

AU - Slaga, Thomas J.

N1 - Funding Information: This work was supported in part by the U.S. Public Health Service (grant no. CA47964).

PY - 1993/9/30

Y1 - 1993/9/30

N2 - Benz[j]aceanthrylene (B[j]A), a cyclopenta-fused derivative of benz[a]anthracene, has been reported to be an active bacterial cell and mammalian cell gene mutagen, a morphological transforming agent in C3H10T 1 2CL8 mouse embryo fibroblasts and a mouse lung tumorigen in strain A J mice. B[j]A was evaluated as a skin tumor initiator in female SENCAR mice and was found to induce papilloma formation in the range of 40-400 μg/mouse. B[j]A was found to be extremely active, inducing 8.7 papillomas/mouse after an initiating dose of 40 μg/mouse. At this dose, 100% of the mice bore tumors. Comparison with four other cyclopenta-fused polycyclic aromatic hydrocarbons suggests that B[j]A is extremely potent.

AB - Benz[j]aceanthrylene (B[j]A), a cyclopenta-fused derivative of benz[a]anthracene, has been reported to be an active bacterial cell and mammalian cell gene mutagen, a morphological transforming agent in C3H10T 1 2CL8 mouse embryo fibroblasts and a mouse lung tumorigen in strain A J mice. B[j]A was evaluated as a skin tumor initiator in female SENCAR mice and was found to induce papilloma formation in the range of 40-400 μg/mouse. B[j]A was found to be extremely active, inducing 8.7 papillomas/mouse after an initiating dose of 40 μg/mouse. At this dose, 100% of the mice bore tumors. Comparison with four other cyclopenta-fused polycyclic aromatic hydrocarbons suggests that B[j]A is extremely potent.

KW - Benz[j]aceanthrylene

KW - SENCAR mice

KW - Tumor initiation

KW - benzo[a]pyrene

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AN - SCOPUS:0027427977

SN - 0304-3835

VL - 73

SP - 73

EP - 76

JO - Cancer Letters

JF - Cancer Letters

IS - 2-3

ER -

Mouse skin tumor-initiating activity of benz[j]aceanthrylene in SENCAR mice

Abstract

Keywords

ASJC Scopus subject areas

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