Mouse skin tumor-initiating activity of benz[j]aceanthrylene in SENCAR mice

Stephen Nesnow, Avram Gold, R. Sangaiah, Thomas J. Slaga

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Benz[j]aceanthrylene (B[j]A), a cyclopenta-fused derivative of benz[a]anthracene, has been reported to be an active bacterial cell and mammalian cell gene mutagen, a morphological transforming agent in C3H10T 1 2CL8 mouse embryo fibroblasts and a mouse lung tumorigen in strain A J mice. B[j]A was evaluated as a skin tumor initiator in female SENCAR mice and was found to induce papilloma formation in the range of 40-400 μg/mouse. B[j]A was found to be extremely active, inducing 8.7 papillomas/mouse after an initiating dose of 40 μg/mouse. At this dose, 100% of the mice bore tumors. Comparison with four other cyclopenta-fused polycyclic aromatic hydrocarbons suggests that B[j]A is extremely potent.

Original languageEnglish (US)
Pages (from-to)73-76
Number of pages4
JournalCancer Letters
Volume73
Issue number2-3
DOIs
StatePublished - Sep 30 1993
Externally publishedYes

Keywords

  • Benz[j]aceanthrylene
  • SENCAR mice
  • Tumor initiation
  • benzo[a]pyrene

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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