Mouse skin tumor-initiating activity of benz[e]aceanthrylene and benz[l]aceanthrylene in SENCAR mice

Stephen Nesnow, Avram Gold, R. Sangaiah, Larry L. Triplett, Thomas J Slaga

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)263-268
Number of pages6
JournalCancer Letters
Volume22
Issue number3
DOIs
StatePublished - 1984
Externally publishedYes

Fingerprint

Inbred SENCAR Mouse
Polycyclic Aromatic Hydrocarbons
Skin
Carcinogens
Neoplasms
Air Pollutants
Benzo(a)pyrene
Air Pollution
Mutagens
Papilloma
Carcinogenesis
benz(e)aceanthrylene
benz(l)aceanthrylene
Genes

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Mouse skin tumor-initiating activity of benz[e]aceanthrylene and benz[l]aceanthrylene in SENCAR mice. / Nesnow, Stephen; Gold, Avram; Sangaiah, R.; Triplett, Larry L.; Slaga, Thomas J.

In: Cancer Letters, Vol. 22, No. 3, 1984, p. 263-268.

Research output: Contribution to journalArticle

Nesnow, Stephen ; Gold, Avram ; Sangaiah, R. ; Triplett, Larry L. ; Slaga, Thomas J. / Mouse skin tumor-initiating activity of benz[e]aceanthrylene and benz[l]aceanthrylene in SENCAR mice. In: Cancer Letters. 1984 ; Vol. 22, No. 3. pp. 263-268.
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title = "Mouse skin tumor-initiating activity of benz[e]aceanthrylene and benz[l]aceanthrylene in SENCAR mice",
abstract = "Benz[e]aceanthrylene (B[e]A) and benz[l]aceanthrylene (B[l]A), cyclopenta-fused derivatives of benz[a]anthracene, have been reported to be active bacterial cell and mammalian cell gene mutagens. In this study they were evaluated as skin tumor initiators in both male and female SENCAR mice. Both polycyclic aromatic hydrocarbons (PAHs) induced papilloma formation in the range of 50-1000 nmol/mouse. B[l]A was the most active, being approximately 4 times as active as benzo[a]pyrene (B[a]P) while B[e]A had activity approximately equivalent to B[a]P. These results are in contrast to those reported for the air pollutant, cyclopenta[cd]pyrene, another cyclopenta-fused PAH, which is a weak mouse skin tumor initiator. We postulate that these cyclopenta-PAHs are formed by pyrosynthetic routes similar to other environmental cyclopenta-PAHs and that they may be of importance as contributors to air pollution carcinogenesis.",
author = "Stephen Nesnow and Avram Gold and R. Sangaiah and Triplett, {Larry L.} and Slaga, {Thomas J}",
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AU - Nesnow, Stephen

AU - Gold, Avram

AU - Sangaiah, R.

AU - Triplett, Larry L.

AU - Slaga, Thomas J

PY - 1984

Y1 - 1984

N2 - Benz[e]aceanthrylene (B[e]A) and benz[l]aceanthrylene (B[l]A), cyclopenta-fused derivatives of benz[a]anthracene, have been reported to be active bacterial cell and mammalian cell gene mutagens. In this study they were evaluated as skin tumor initiators in both male and female SENCAR mice. Both polycyclic aromatic hydrocarbons (PAHs) induced papilloma formation in the range of 50-1000 nmol/mouse. B[l]A was the most active, being approximately 4 times as active as benzo[a]pyrene (B[a]P) while B[e]A had activity approximately equivalent to B[a]P. These results are in contrast to those reported for the air pollutant, cyclopenta[cd]pyrene, another cyclopenta-fused PAH, which is a weak mouse skin tumor initiator. We postulate that these cyclopenta-PAHs are formed by pyrosynthetic routes similar to other environmental cyclopenta-PAHs and that they may be of importance as contributors to air pollution carcinogenesis.

AB - Benz[e]aceanthrylene (B[e]A) and benz[l]aceanthrylene (B[l]A), cyclopenta-fused derivatives of benz[a]anthracene, have been reported to be active bacterial cell and mammalian cell gene mutagens. In this study they were evaluated as skin tumor initiators in both male and female SENCAR mice. Both polycyclic aromatic hydrocarbons (PAHs) induced papilloma formation in the range of 50-1000 nmol/mouse. B[l]A was the most active, being approximately 4 times as active as benzo[a]pyrene (B[a]P) while B[e]A had activity approximately equivalent to B[a]P. These results are in contrast to those reported for the air pollutant, cyclopenta[cd]pyrene, another cyclopenta-fused PAH, which is a weak mouse skin tumor initiator. We postulate that these cyclopenta-PAHs are formed by pyrosynthetic routes similar to other environmental cyclopenta-PAHs and that they may be of importance as contributors to air pollution carcinogenesis.

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