Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 263-268 |
| Number of pages | 6 |
| Journal | Cancer Letters |
| Volume | 22 |
| Issue number | 3 |
| DOIs | |
| State | Published - 1984 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Molecular Biology
- Oncology
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Mouse skin tumor-initiating activity of benz[e]aceanthrylene and benz[l]aceanthrylene in SENCAR mice. / Nesnow, Stephen; Gold, Avram; Sangaiah, R.; Triplett, Larry L.; Slaga, Thomas J.
In: Cancer Letters, Vol. 22, No. 3, 1984, p. 263-268.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Mouse skin tumor-initiating activity of benz[e]aceanthrylene and benz[l]aceanthrylene in SENCAR mice
AU - Nesnow, Stephen
AU - Gold, Avram
AU - Sangaiah, R.
AU - Triplett, Larry L.
AU - Slaga, Thomas J
PY - 1984
Y1 - 1984
N2 - Benz[e]aceanthrylene (B[e]A) and benz[l]aceanthrylene (B[l]A), cyclopenta-fused derivatives of benz[a]anthracene, have been reported to be active bacterial cell and mammalian cell gene mutagens. In this study they were evaluated as skin tumor initiators in both male and female SENCAR mice. Both polycyclic aromatic hydrocarbons (PAHs) induced papilloma formation in the range of 50-1000 nmol/mouse. B[l]A was the most active, being approximately 4 times as active as benzo[a]pyrene (B[a]P) while B[e]A had activity approximately equivalent to B[a]P. These results are in contrast to those reported for the air pollutant, cyclopenta[cd]pyrene, another cyclopenta-fused PAH, which is a weak mouse skin tumor initiator. We postulate that these cyclopenta-PAHs are formed by pyrosynthetic routes similar to other environmental cyclopenta-PAHs and that they may be of importance as contributors to air pollution carcinogenesis.
AB - Benz[e]aceanthrylene (B[e]A) and benz[l]aceanthrylene (B[l]A), cyclopenta-fused derivatives of benz[a]anthracene, have been reported to be active bacterial cell and mammalian cell gene mutagens. In this study they were evaluated as skin tumor initiators in both male and female SENCAR mice. Both polycyclic aromatic hydrocarbons (PAHs) induced papilloma formation in the range of 50-1000 nmol/mouse. B[l]A was the most active, being approximately 4 times as active as benzo[a]pyrene (B[a]P) while B[e]A had activity approximately equivalent to B[a]P. These results are in contrast to those reported for the air pollutant, cyclopenta[cd]pyrene, another cyclopenta-fused PAH, which is a weak mouse skin tumor initiator. We postulate that these cyclopenta-PAHs are formed by pyrosynthetic routes similar to other environmental cyclopenta-PAHs and that they may be of importance as contributors to air pollution carcinogenesis.
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U2 - 10.1016/0304-3835(84)90161-7
DO - 10.1016/0304-3835(84)90161-7
M3 - Article
C2 - 6713367
AN - SCOPUS:0021214493
VL - 22
SP - 263
EP - 268
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 3
ER -