Mouse skin tumor-initiating activity of benz[e]aceanthrylene and benz[l]aceanthrylene in SENCAR mice

Stephen Nesnow; Avram Gold; R. Sangaiah; Larry L. Triplett; Thomas J. Slaga

doi:10.1016/0304-3835(84)90161-7

Mouse skin tumor-initiating activity of benz[e]aceanthrylene and benz[l]aceanthrylene in SENCAR mice

Stephen Nesnow, Avram Gold, R. Sangaiah, Larry L. Triplett, Thomas J. Slaga

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Benz[e]aceanthrylene (B[e]A) and benz[l]aceanthrylene (B[l]A), cyclopenta-fused derivatives of benz[a]anthracene, have been reported to be active bacterial cell and mammalian cell gene mutagens. In this study they were evaluated as skin tumor initiators in both male and female SENCAR mice. Both polycyclic aromatic hydrocarbons (PAHs) induced papilloma formation in the range of 50-1000 nmol/mouse. B[l]A was the most active, being approximately 4 times as active as benzo[a]pyrene (B[a]P) while B[e]A had activity approximately equivalent to B[a]P. These results are in contrast to those reported for the air pollutant, cyclopenta[cd]pyrene, another cyclopenta-fused PAH, which is a weak mouse skin tumor initiator. We postulate that these cyclopenta-PAHs are formed by pyrosynthetic routes similar to other environmental cyclopenta-PAHs and that they may be of importance as contributors to air pollution carcinogenesis.

Original language	English (US)
Pages (from-to)	263-268
Number of pages	6
Journal	Cancer Letters
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/0304-3835(84)90161-7
State	Published - Apr 1984
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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@article{c6d77c5e7bcb482288445501be4d9166,

title = "Mouse skin tumor-initiating activity of benz[e]aceanthrylene and benz[l]aceanthrylene in SENCAR mice",

abstract = "Benz[e]aceanthrylene (B[e]A) and benz[l]aceanthrylene (B[l]A), cyclopenta-fused derivatives of benz[a]anthracene, have been reported to be active bacterial cell and mammalian cell gene mutagens. In this study they were evaluated as skin tumor initiators in both male and female SENCAR mice. Both polycyclic aromatic hydrocarbons (PAHs) induced papilloma formation in the range of 50-1000 nmol/mouse. B[l]A was the most active, being approximately 4 times as active as benzo[a]pyrene (B[a]P) while B[e]A had activity approximately equivalent to B[a]P. These results are in contrast to those reported for the air pollutant, cyclopenta[cd]pyrene, another cyclopenta-fused PAH, which is a weak mouse skin tumor initiator. We postulate that these cyclopenta-PAHs are formed by pyrosynthetic routes similar to other environmental cyclopenta-PAHs and that they may be of importance as contributors to air pollution carcinogenesis.",

author = "Stephen Nesnow and Avram Gold and R. Sangaiah and Triplett, {Larry L.} and Slaga, {Thomas J.}",

note = "Funding Information: The authors thank l{\textquoteright}v?sJ. oye Denning and Ms. Hinda Bergman for their skillful preparation of this manuscript. This work was supported by the U.S. Environmental Protection Agency, contract 79D-X0526, under interagency agreement 40-728-78 with the U.S. Department of Energy through the Office of Health and Environmental Research, U.S. Department of Energy, under contract 7405 eng-26 with Union Carbide Corporation. This report has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the U.S. Environmental Protection Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use.",

year = "1984",

month = apr,

doi = "10.1016/0304-3835(84)90161-7",

language = "English (US)",

volume = "22",

pages = "263--268",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "3",

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TY - JOUR

T1 - Mouse skin tumor-initiating activity of benz[e]aceanthrylene and benz[l]aceanthrylene in SENCAR mice

AU - Nesnow, Stephen

AU - Gold, Avram

AU - Sangaiah, R.

AU - Triplett, Larry L.

AU - Slaga, Thomas J.

N1 - Funding Information: The authors thank l’v?sJ. oye Denning and Ms. Hinda Bergman for their skillful preparation of this manuscript. This work was supported by the U.S. Environmental Protection Agency, contract 79D-X0526, under interagency agreement 40-728-78 with the U.S. Department of Energy through the Office of Health and Environmental Research, U.S. Department of Energy, under contract 7405 eng-26 with Union Carbide Corporation. This report has been reviewed by the Health Effects Research Laboratory, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the U.S. Environmental Protection Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use.

PY - 1984/4

Y1 - 1984/4

N2 - Benz[e]aceanthrylene (B[e]A) and benz[l]aceanthrylene (B[l]A), cyclopenta-fused derivatives of benz[a]anthracene, have been reported to be active bacterial cell and mammalian cell gene mutagens. In this study they were evaluated as skin tumor initiators in both male and female SENCAR mice. Both polycyclic aromatic hydrocarbons (PAHs) induced papilloma formation in the range of 50-1000 nmol/mouse. B[l]A was the most active, being approximately 4 times as active as benzo[a]pyrene (B[a]P) while B[e]A had activity approximately equivalent to B[a]P. These results are in contrast to those reported for the air pollutant, cyclopenta[cd]pyrene, another cyclopenta-fused PAH, which is a weak mouse skin tumor initiator. We postulate that these cyclopenta-PAHs are formed by pyrosynthetic routes similar to other environmental cyclopenta-PAHs and that they may be of importance as contributors to air pollution carcinogenesis.

AB - Benz[e]aceanthrylene (B[e]A) and benz[l]aceanthrylene (B[l]A), cyclopenta-fused derivatives of benz[a]anthracene, have been reported to be active bacterial cell and mammalian cell gene mutagens. In this study they were evaluated as skin tumor initiators in both male and female SENCAR mice. Both polycyclic aromatic hydrocarbons (PAHs) induced papilloma formation in the range of 50-1000 nmol/mouse. B[l]A was the most active, being approximately 4 times as active as benzo[a]pyrene (B[a]P) while B[e]A had activity approximately equivalent to B[a]P. These results are in contrast to those reported for the air pollutant, cyclopenta[cd]pyrene, another cyclopenta-fused PAH, which is a weak mouse skin tumor initiator. We postulate that these cyclopenta-PAHs are formed by pyrosynthetic routes similar to other environmental cyclopenta-PAHs and that they may be of importance as contributors to air pollution carcinogenesis.

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AN - SCOPUS:0021214493

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JF - Cancer Letters

SN - 0304-3835

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ER -

Mouse skin tumor-initiating activity of benz[e]aceanthrylene and benz[l]aceanthrylene in SENCAR mice

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