Mouse models of severe asthma for evaluation of therapeutic cytokine targeting

Ekaterina O. Gubernatorova, Olga A. Namakanova, Alexei V Tumanov, Marina S. Drutskaya, Sergei A. Nedospasov

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Severe asthma is a heterogeneous inflammatory disease of the airways, which requires treatment with high-dose inhaled corticosteroids or their systemic administration, yet often remains uncontrolled despite this therapy. Over the past decades, research efforts into phenotyping of severe asthma and defining the pathological mechanisms of this disease were successful largely due to the development of appropriate animal models. Recent identification of distinct inflammatory patterns of severe asthma endotypes led to novel treatment approaches, including targeting specific cytokines or their receptors with neutralizing antibodies. Here we discuss how different experimental mouse models contributed to generation of clinically relevant findings concerning pathogenesis of severe asthma and to identification of potential targets for biologic therapy.

Original languageEnglish (US)
Pages (from-to)73-83
Number of pages11
JournalImmunology Letters
Volume207
DOIs
StatePublished - Mar 1 2019

Keywords

  • Anti-cytokine therapy
  • Asthma treatment
  • Cytokines
  • Mouse models
  • Severe asthma
  • Steroid-resistant asthma

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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