Morphometric analysis of germinal centers in nonthymomatous patients with myasthenia gravis

C. A. Moran, S. Suster, J. Gil, J. Jagirdar

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A morphometric analysis of germinal centers (GCs) in the thymus of nonthymomatous patients with myasthenia gravis was performed in 26 patients, including 14 women and 12 men. The GCs were evaluated for number, diameter, perimeter, and cross-sectional area using a computerized interactive morphometric analysis. The GCs ranged from 2 to 19 per case, with an average diameter of 0.02 to 0.43 mm, a perimeter of 0.38 to 1.35 mm, and a cross-sectional area of 0.01 to 0.14 mm2. In thymic sections with fewer than five GCs, the GCs had a mean area of 0.05 mm2, a perimeter of 0.84 mm, and a diameter of 0.24 mm. In thymic sections containing five or more GCs, the GCs had a mean area of 0.04 mm2, a perimeter of 0.62 mm, and a diameter of 0.19 mm. The clinical improvement in these patients inversely correlated with the above parameters, with improvement being observed in patients whose GCs had a mean area of 0.02 mm2, a perimeter of 0.58 mm, and a diameter of 0.17 mm. No corelation was observed between the number of GCs and clinical improvement. The results of our study appear to indicate that computerized interactive morphometric analysis may represent a potentially useful method for the evaluation of the morphometric features of thymic GCs and their correlation with clinical outcome in patients with myasthenia gravis.

Original languageEnglish (US)
Pages (from-to)689-691
Number of pages3
JournalArchives of Pathology and Laboratory Medicine
Volume114
Issue number7
StatePublished - 1990
Externally publishedYes

Fingerprint

Germinal Center
Myasthenia Gravis
Thymus Gland

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Cite this

Morphometric analysis of germinal centers in nonthymomatous patients with myasthenia gravis. / Moran, C. A.; Suster, S.; Gil, J.; Jagirdar, J.

In: Archives of Pathology and Laboratory Medicine, Vol. 114, No. 7, 1990, p. 689-691.

Research output: Contribution to journalArticle

Moran, C. A. ; Suster, S. ; Gil, J. ; Jagirdar, J. / Morphometric analysis of germinal centers in nonthymomatous patients with myasthenia gravis. In: Archives of Pathology and Laboratory Medicine. 1990 ; Vol. 114, No. 7. pp. 689-691.
@article{151a8c3a56744dd7b25cabd2671ffee3,
title = "Morphometric analysis of germinal centers in nonthymomatous patients with myasthenia gravis",
abstract = "A morphometric analysis of germinal centers (GCs) in the thymus of nonthymomatous patients with myasthenia gravis was performed in 26 patients, including 14 women and 12 men. The GCs were evaluated for number, diameter, perimeter, and cross-sectional area using a computerized interactive morphometric analysis. The GCs ranged from 2 to 19 per case, with an average diameter of 0.02 to 0.43 mm, a perimeter of 0.38 to 1.35 mm, and a cross-sectional area of 0.01 to 0.14 mm2. In thymic sections with fewer than five GCs, the GCs had a mean area of 0.05 mm2, a perimeter of 0.84 mm, and a diameter of 0.24 mm. In thymic sections containing five or more GCs, the GCs had a mean area of 0.04 mm2, a perimeter of 0.62 mm, and a diameter of 0.19 mm. The clinical improvement in these patients inversely correlated with the above parameters, with improvement being observed in patients whose GCs had a mean area of 0.02 mm2, a perimeter of 0.58 mm, and a diameter of 0.17 mm. No corelation was observed between the number of GCs and clinical improvement. The results of our study appear to indicate that computerized interactive morphometric analysis may represent a potentially useful method for the evaluation of the morphometric features of thymic GCs and their correlation with clinical outcome in patients with myasthenia gravis.",
author = "Moran, {C. A.} and S. Suster and J. Gil and J. Jagirdar",
year = "1990",
language = "English (US)",
volume = "114",
pages = "689--691",
journal = "Archives of Pathology and Laboratory Medicine",
issn = "0003-9985",
publisher = "College of American Pathologists",
number = "7",

}

TY - JOUR

T1 - Morphometric analysis of germinal centers in nonthymomatous patients with myasthenia gravis

AU - Moran, C. A.

AU - Suster, S.

AU - Gil, J.

AU - Jagirdar, J.

PY - 1990

Y1 - 1990

N2 - A morphometric analysis of germinal centers (GCs) in the thymus of nonthymomatous patients with myasthenia gravis was performed in 26 patients, including 14 women and 12 men. The GCs were evaluated for number, diameter, perimeter, and cross-sectional area using a computerized interactive morphometric analysis. The GCs ranged from 2 to 19 per case, with an average diameter of 0.02 to 0.43 mm, a perimeter of 0.38 to 1.35 mm, and a cross-sectional area of 0.01 to 0.14 mm2. In thymic sections with fewer than five GCs, the GCs had a mean area of 0.05 mm2, a perimeter of 0.84 mm, and a diameter of 0.24 mm. In thymic sections containing five or more GCs, the GCs had a mean area of 0.04 mm2, a perimeter of 0.62 mm, and a diameter of 0.19 mm. The clinical improvement in these patients inversely correlated with the above parameters, with improvement being observed in patients whose GCs had a mean area of 0.02 mm2, a perimeter of 0.58 mm, and a diameter of 0.17 mm. No corelation was observed between the number of GCs and clinical improvement. The results of our study appear to indicate that computerized interactive morphometric analysis may represent a potentially useful method for the evaluation of the morphometric features of thymic GCs and their correlation with clinical outcome in patients with myasthenia gravis.

AB - A morphometric analysis of germinal centers (GCs) in the thymus of nonthymomatous patients with myasthenia gravis was performed in 26 patients, including 14 women and 12 men. The GCs were evaluated for number, diameter, perimeter, and cross-sectional area using a computerized interactive morphometric analysis. The GCs ranged from 2 to 19 per case, with an average diameter of 0.02 to 0.43 mm, a perimeter of 0.38 to 1.35 mm, and a cross-sectional area of 0.01 to 0.14 mm2. In thymic sections with fewer than five GCs, the GCs had a mean area of 0.05 mm2, a perimeter of 0.84 mm, and a diameter of 0.24 mm. In thymic sections containing five or more GCs, the GCs had a mean area of 0.04 mm2, a perimeter of 0.62 mm, and a diameter of 0.19 mm. The clinical improvement in these patients inversely correlated with the above parameters, with improvement being observed in patients whose GCs had a mean area of 0.02 mm2, a perimeter of 0.58 mm, and a diameter of 0.17 mm. No corelation was observed between the number of GCs and clinical improvement. The results of our study appear to indicate that computerized interactive morphometric analysis may represent a potentially useful method for the evaluation of the morphometric features of thymic GCs and their correlation with clinical outcome in patients with myasthenia gravis.

UR - http://www.scopus.com/inward/record.url?scp=0025322985&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025322985&partnerID=8YFLogxK

M3 - Article

C2 - 2363627

AN - SCOPUS:0025322985

VL - 114

SP - 689

EP - 691

JO - Archives of Pathology and Laboratory Medicine

JF - Archives of Pathology and Laboratory Medicine

SN - 0003-9985

IS - 7

ER -