Morphological basis for polypeptide hormone secretion by pineal gland of Macacus rhesus (Polish)

A. Lukaszyk, R. J. Reiter

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Abstract

Using histochemical methods to demonstrate the neurosecretion of polypeptide endocrine cells the authors visualize characteristic substances in some areas of the pineal of an adult monkey. The substances were present in single nervous fibres, within perivascular space, and around and within at least one layer of multilayer corpuscles. The accompanying glial cells often contained a granular material. The substances were stained red with Gomori's method. In those in perivascular space and multilayer corpuscles calcium was detectable histochemically. Since these phenomena may correspond to 'peptidergic' neurosecretion, but tinctorially different than in the hypothalamic system, the authors made the hypothesis that a neurosecretory mechanism was responsible for or contributed to polypeptide hormone secretion in the pineals of primates. According to this hypothesis, hormones are released into perivascular space as a carrier protein hormone complex in which, at the moment of incretion calcium ions are substituted for the hormone. Finally, the newly formed complex (carrier Ca) is deposited forming or enlarging multilayer corpuscles corresponding to pineal sand.

Original languageEnglish (US)
Pages (from-to)603-611
Number of pages9
JournalEndokrynologia Polska
Volume26
Issue number6
StatePublished - Jan 1 1975
Externally publishedYes

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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