Morphologic Analysis of the Cerebral Microcirculation after Thermal Injury and the Response to Fluid Resuscitation

M. Barone, F. Jimenez, V. H. Huxley, X. F. Yang

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Using the pial window model, we have previously demonstrated that there is a disruption of the blood brain barrier with distal thermal injury [1-3]. Our laboratory has shown that treatment with Lactated Ringer's Solution did not improve labeled albumin leakage. However, treatment with hypertonic hyperosmotic saline (HHS) solution post thermal injury seemed to essentially eliminate the albumin leakage in cerebral vessels. Using adult Sprague-Dawley rats and epifluorescent microscopy, the cerebral vessel size and diameter were measured, as well as the number of leukocytes rolling or adherent to the endothelium. The results show that there was significant progressive arterial dilatation over six hours in the thermally injured animals treated with HHS. There was also a significant increase in leukocyte number if the animals were thermally injured and had no resuscitation fluid or if the animals were thermally injured and underwent resuscitation fluid with Lactated Ringer's compared to either the control group or the group that was treated with HHS after thermal injury.

Original languageEnglish (US)
Pages (from-to)267-268
Number of pages2
JournalActa Neurochirurgica, Supplement
Volume1997
Issue number70
DOIs
StatePublished - Jan 1 1997

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Keywords

  • Cerebral microcirculation
  • Hypertonic hyperosmotic saline
  • Lactated Ringer's solution
  • Resuscitation
  • Thermal injury

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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