Mood Stabilizers: Quetiapine

Amanda Silva de Miranda, Rodrigo Novaes Ferreira, Antônio Lúcio Teixeira, Aline Silva de Miranda

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Quetiapine is an atypical antipsychotic primarily designed for the management of schizophrenia. However, over the past decades, quetiapine has also been employed as a mood stabilizer receiving Food and Drug Administration approval as monotherapy or adjunctive therapy for conditions like bipolar disorder or major depressive disorder. Moreover, quetiapine has been prescribed off-label for several neuropsychiatric conditions including, among others, generalized anxiety disorder, personality and sleep disorders, delirium, and psychiatric aspects of dementia. The mechanisms underlying the mood-stabilizing actions of quetiapine remain poorly understood. It has been reported that, in combination with its primary metabolite norquetiapine, quetiapine modulates several neurotransmitter systems like serotonin, dopamine, noradrenaline, and histamine. Although generally regarded as a more tolerable and safe compound compared to other atypical antipsychotics, by acting on several neurotransmitters, quetiapine may carry out some adverse effects such as sedation, weight gain, dry mouth, and diabetes. It is worth mentioning that a higher risk of misuse/abuse of quetiapine has also been reported compared with other antipsychotics. Herein, quetiapine chemistry and developmental history as well as pharmacological and clinical aspects are covered.

Original languageEnglish (US)
Title of host publicationNeuroPsychopharmacotherapy
PublisherSpringer International Publishing
Pages1583-1605
Number of pages23
ISBN (Electronic)9783030620592
ISBN (Print)9783030620585
DOIs
StatePublished - Jan 1 2022
Externally publishedYes

ASJC Scopus subject areas

  • General Medicine
  • General Pharmacology, Toxicology and Pharmaceutics

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