Monoclonal antibodies to periodontal ligament cells.

W. T. DuBois, J. Edmondson, S. B. Milam, W. B. Winborn, R. Hay, D. L. Carnes, K. S. Kornman, R. J. Klebe

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Ten mouse monoclonal antibodies were prepared against cultured bovine periodontal ligament cells to be used as reagents for the study of periodontal disease and wound healing. Using standard immunohistochemical methods, these antibodies were found to recognize cell surface antigens in formalin-fixed bovine periodontium. Three of the 10 monoclonal antibodies (i.e., PDL-1, PDL-2, and PDL-10) cross-reacted with cells found in primate periodontium. While the isolated monoclonal antibodies appeared to distinguish subpopulations of cells located in the supporting tissues of teeth, immunohistological examination of other organs (dermis, kidney, skeletal muscle, thyroid, and parotid gland) indicated that a number of cell types of mesenchymal origin share an antigen(s) found on periodontal cells. The monoclonal antibodies described in this report should prove to be useful in studies of periodontal disease and guided tissue regeneration by providing both analytical reagents and immunochemical methods for isolating selected cell populations of the periodontium.

Original languageEnglish (US)
Pages (from-to)190-196
Number of pages7
JournalJournal of periodontology
Issue number3
StatePublished - Mar 1991

ASJC Scopus subject areas

  • Periodontics


Dive into the research topics of 'Monoclonal antibodies to periodontal ligament cells.'. Together they form a unique fingerprint.

Cite this