Molecular prognostics in colorectal cancer

Morton S. Kahlenberg, John M. Sullivan, Diana Dickson Witmer, Nicholas J. Petrelli

Research output: Contribution to journalReview articlepeer-review

42 Scopus citations

Abstract

Conventional staging of colorectal cancer does not account for the marked variability in outcome that exists within each stage. Certain populations of patients with early recurrence, resistance to chemotherapy and decreased survival cannot be predicted utilizing common histopathologic criteria. As the molecular mechanisms underlying colorectal carcinogenesis are elucidated, putative molecular prognostic factors are identified. A comprehensive review of various molecular markers and their roles as prognostic factors in colorectal cancer is presented.

Original languageEnglish (US)
Pages (from-to)173-186
Number of pages14
JournalSurgical Oncology
Volume12
Issue number3
DOIs
StatePublished - Nov 2003

Keywords

  • Colorectal cancer
  • Molecular markers
  • Prognostics

ASJC Scopus subject areas

  • Surgery
  • Oncology

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