Molecular phylogeny and proposal of two new species of the emerging pathogenic fungus Saksenaea

E. Alvarez, D. Garcia-Hermoso, D. A. Sutton, J. F. Cano, A. M. Stchigel, D. Hoinard, A. W. Fothergill, M. G. Rinaldi, F. Dromer, J. Guarro

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Saksenaea is a monotypic genus belonging to the order Mucorales and capable of producing severe human infections. Through a polyphasic study based on analysis of the sequences of the internal transcribed spacer (ITS) region, domains D1 and D2 of the 28S rRNA gene, and the elongation factor 1α (EF-1α) gene, as well as by evaluation of relevant morphological and physiological characteristics of a set of clinical and environmental strains, we have demonstrated that Saksenaea vasiformis is a complex of species. We propose as new species Saksenaea oblongispora, characterized by oblong sporangiospores and unable to grow at 42°C, and Saksenaea erythrospora, characterized by large sporangiophores and sporangia and by ellipsoid sporangiospores, biconcave in the lateral view. Itraconazole, posaconazole, and terbinafine were active against all isolates included in the study, while amphotericin B, voriconazole, and the echinocandins showed low activity.

Original languageEnglish (US)
Pages (from-to)4410-4416
Number of pages7
JournalJournal of clinical microbiology
Volume48
Issue number12
DOIs
StatePublished - Dec 1 2010

ASJC Scopus subject areas

  • Microbiology (medical)

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