Molecular Pathways Involved in the Pathogenesis of Pancreatic Cancer: Role of Phytochemicals in Targeting the Clinical Outcomes

Bayarmaa Mandzhieva, Rima Shobar, Anum Jalil, Hammad Zafar, Mamoon Ur Rashid, Ranjeet Kumar, Akash Khetpal, Sarfraz Ahmad

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. Its high mortality is due to delayed diagnosis as it often produces minimal symptoms early in the disease. Surgical resection, radiation therapy, and chemotherapy are essential treatment components. It is well known that chemotherapy options include gemcitabine monotherapy, 5-fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX) combination and the combination of gemcitabine plus albumin-bound (nab) paclitaxel. Despite these therapeutic options, the average 5-year survival rate continues to be less than 5%; therefore more efficacious approaches need to be explored. There are novel potential therapies under investigation such as immunotherapy and compounds from natural sources. Many recently published epidemiological studies have shown a strong association between phytochemicals and reduced incidence of cancers. This chapter is an overview of the current knowledge and the potential anticancer properties of various natural products, such as curcumin, benzyl isothiocyanate, capsaicin, resveratrol, and tea polyphenols. These findings lay the groundwork to support that there exist some association of anticancer properties of phytochemicals in the management of pancreatic malignancy.

Original languageEnglish (US)
Title of host publicationPhytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers
PublisherSpringer International Publishing
Pages223-260
Number of pages38
ISBN (Electronic)9783030484057
ISBN (Print)9783030484040
DOIs
StatePublished - Jan 1 2020
Externally publishedYes

Keywords

  • Capsaicin
  • Clinical outcomes
  • Curcumin
  • Isothiocyanates
  • Molecular pathways
  • Pancreatic cancer
  • Pathobiology
  • Phytochemicals
  • Quercetin
  • Resveratrol
  • Tea polyphenols

ASJC Scopus subject areas

  • General Medicine

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