Abstract
Axo-glial interactions are required for the organization of highly specialized molecular domains in myelinated axons. The molecular composition of these domains includes cell adhesion molecules, ion channels and cytoskeletal proteins. Recent genetic and molecular studies provide new insights into how these macromolecular complexes are assembled and organized into functional domains, and how the loss of individual components affects domain organization and function. More importantly, the key molecular components identified at the vertebrate axo-glial septate junctions are also present at the Drosophila septate junctions. In addition, new roles for axo-glial paranodal septate junctions have emerged, which suggest that the paranodal region may act as an ionic barrier and a molecular fence in myelinated axons.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 552-559 |
| Number of pages | 8 |
| Journal | Current Opinion in Neurobiology |
| Volume | 13 |
| Issue number | 5 |
| DOIs | |
| State | Published - Oct 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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Molecular organization of axo-glial junctions. / Bhat, Manzoor.
In: Current Opinion in Neurobiology, Vol. 13, No. 5, 10.2003, p. 552-559.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Molecular organization of axo-glial junctions
AU - Bhat, Manzoor
PY - 2003/10
Y1 - 2003/10
N2 - Axo-glial interactions are required for the organization of highly specialized molecular domains in myelinated axons. The molecular composition of these domains includes cell adhesion molecules, ion channels and cytoskeletal proteins. Recent genetic and molecular studies provide new insights into how these macromolecular complexes are assembled and organized into functional domains, and how the loss of individual components affects domain organization and function. More importantly, the key molecular components identified at the vertebrate axo-glial septate junctions are also present at the Drosophila septate junctions. In addition, new roles for axo-glial paranodal septate junctions have emerged, which suggest that the paranodal region may act as an ionic barrier and a molecular fence in myelinated axons.
AB - Axo-glial interactions are required for the organization of highly specialized molecular domains in myelinated axons. The molecular composition of these domains includes cell adhesion molecules, ion channels and cytoskeletal proteins. Recent genetic and molecular studies provide new insights into how these macromolecular complexes are assembled and organized into functional domains, and how the loss of individual components affects domain organization and function. More importantly, the key molecular components identified at the vertebrate axo-glial septate junctions are also present at the Drosophila septate junctions. In addition, new roles for axo-glial paranodal septate junctions have emerged, which suggest that the paranodal region may act as an ionic barrier and a molecular fence in myelinated axons.
UR - http://www.scopus.com/inward/record.url?scp=0242487890&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0242487890&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2003.09.004
DO - 10.1016/j.conb.2003.09.004
M3 - Article
C2 - 14630217
AN - SCOPUS:0242487890
VL - 13
SP - 552
EP - 559
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
SN - 0959-4388
IS - 5
ER -