Molecular organization of axo-glial junctions

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Axo-glial interactions are required for the organization of highly specialized molecular domains in myelinated axons. The molecular composition of these domains includes cell adhesion molecules, ion channels and cytoskeletal proteins. Recent genetic and molecular studies provide new insights into how these macromolecular complexes are assembled and organized into functional domains, and how the loss of individual components affects domain organization and function. More importantly, the key molecular components identified at the vertebrate axo-glial septate junctions are also present at the Drosophila septate junctions. In addition, new roles for axo-glial paranodal septate junctions have emerged, which suggest that the paranodal region may act as an ionic barrier and a molecular fence in myelinated axons.

Original languageEnglish (US)
Pages (from-to)552-559
Number of pages8
JournalCurrent Opinion in Neurobiology
Volume13
Issue number5
DOIs
StatePublished - Oct 2003
Externally publishedYes

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Neuroglia
Axons
Macromolecular Substances
Cytoskeletal Proteins
Cell Adhesion Molecules
Ion Channels
Drosophila
Vertebrates
Molecular Biology

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Molecular organization of axo-glial junctions. / Bhat, Manzoor.

In: Current Opinion in Neurobiology, Vol. 13, No. 5, 10.2003, p. 552-559.

Research output: Contribution to journalArticle

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