Molecular mechanisms of melatonin's inhibitory actions on breast cancers

Sara Proietti, Alessandra Cucina, Russel J Reiter, Mariano Bizzarri

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)2139-2157
Number of pages19
JournalCellular and Molecular Life Sciences
Volume70
Issue number12
DOIs
StatePublished - Jun 2013

Fingerprint

Melatonin
Breast Neoplasms
Neoplasms
Pathologic Processes
Cell Differentiation
Hormones
Apoptosis
Cell Line
Incidence
Growth

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Molecular mechanisms of melatonin's inhibitory actions on breast cancers. / Proietti, Sara; Cucina, Alessandra; Reiter, Russel J; Bizzarri, Mariano.

In: Cellular and Molecular Life Sciences, Vol. 70, No. 12, 06.2013, p. 2139-2157.

Research output: Contribution to journalArticle

Proietti, Sara ; Cucina, Alessandra ; Reiter, Russel J ; Bizzarri, Mariano. / Molecular mechanisms of melatonin's inhibitory actions on breast cancers. In: Cellular and Molecular Life Sciences. 2013 ; Vol. 70, No. 12. pp. 2139-2157.
@article{46cb8488f4974e7c993ddfe8fd893f98,
title = "Molecular mechanisms of melatonin's inhibitory actions on breast cancers",
abstract = "Melatonin is involved in many physiological functions and it plays an important role in many pathological processes as well. Melatonin has been shown to reduce the incidence of experimentally induced cancers and can significantly inhibit the growth of some human tumors, namely hormone-dependent cancers. The anticancer effects of melatonin have been observed in breast cancer, both in in vivo with models of chemically induced rat mammary tumors, and in vitro studies on human breast cancer cell lines. Melatonin acts at different physiological levels and its antitumoral properties are supported by a set of complex, different mechanisms of action, involving apoptosis activation, inhibition of proliferation, and cell differentiation.",
keywords = "Apoptosis, Breast cancer, Cell morphology, Epigenetic effects, Growth inhibition, Melatonin",
author = "Sara Proietti and Alessandra Cucina and Reiter, {Russel J} and Mariano Bizzarri",
year = "2013",
month = "6",
doi = "10.1007/s00018-012-1161-8",
language = "English",
volume = "70",
pages = "2139--2157",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "12",

}

TY - JOUR

T1 - Molecular mechanisms of melatonin's inhibitory actions on breast cancers

AU - Proietti, Sara

AU - Cucina, Alessandra

AU - Reiter, Russel J

AU - Bizzarri, Mariano

PY - 2013/6

Y1 - 2013/6

N2 - Melatonin is involved in many physiological functions and it plays an important role in many pathological processes as well. Melatonin has been shown to reduce the incidence of experimentally induced cancers and can significantly inhibit the growth of some human tumors, namely hormone-dependent cancers. The anticancer effects of melatonin have been observed in breast cancer, both in in vivo with models of chemically induced rat mammary tumors, and in vitro studies on human breast cancer cell lines. Melatonin acts at different physiological levels and its antitumoral properties are supported by a set of complex, different mechanisms of action, involving apoptosis activation, inhibition of proliferation, and cell differentiation.

AB - Melatonin is involved in many physiological functions and it plays an important role in many pathological processes as well. Melatonin has been shown to reduce the incidence of experimentally induced cancers and can significantly inhibit the growth of some human tumors, namely hormone-dependent cancers. The anticancer effects of melatonin have been observed in breast cancer, both in in vivo with models of chemically induced rat mammary tumors, and in vitro studies on human breast cancer cell lines. Melatonin acts at different physiological levels and its antitumoral properties are supported by a set of complex, different mechanisms of action, involving apoptosis activation, inhibition of proliferation, and cell differentiation.

KW - Apoptosis

KW - Breast cancer

KW - Cell morphology

KW - Epigenetic effects

KW - Growth inhibition

KW - Melatonin

UR - http://www.scopus.com/inward/record.url?scp=84878597737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84878597737&partnerID=8YFLogxK

U2 - 10.1007/s00018-012-1161-8

DO - 10.1007/s00018-012-1161-8

M3 - Article

VL - 70

SP - 2139

EP - 2157

JO - Cellular and Molecular Life Sciences

JF - Cellular and Molecular Life Sciences

SN - 1420-682X

IS - 12

ER -