Molecular mechanisms governing reading frame choice of immunoglobulin diversity genes

Frank M. Raaphorst, C. S. Raman, Barry T. Nall, Judy M. Teale

Research output: Contribution to journalComment/debatepeer-review

36 Scopus citations

Abstract

The key elements of antigen-binding immunoglobulin (Ig) variable regions are primarily encoded by diversity (D(H)) genes. Although D(H) genes can be used in all three reading frames, the majority of peripheral Ig molecules carry a D(H) element in a single reading frame. Here, Frank Raaphorst, C. Raman, Barry Nall and Judy Teale discuss the particular demands imposed by the structure of the antigen-binding site, which determine the choice of reading frame.

Original languageEnglish (US)
Pages (from-to)37-43
Number of pages7
JournalImmunology today
Volume18
Issue number1
DOIs
StatePublished - Jan 1997

ASJC Scopus subject areas

  • Immunology

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