Molecular genetics of lung and pleural neoplasms

Philip T. Cagle, Jaishree Jagirdar, Helmut H. Popper

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Molecular pathology involves study of nucleic acids, genes, and gene products.1-9 The development and progression of human cancers are linked to genetic instability and the accumulation of multiple genetic mutations, which can be investigated with the tools of molecular pathology.10-25 Molecular pathology provides a basis for understanding the biology of lung cancer,26-36 including its pathogenetic relationship to tobacco smoking,37-57 and increasingly is providing targets for therapeutic intervention. 58-78 In this section, we briefly review the basic terminology and concepts, as an introduction or refresher to subsequent sections of this chapter, and we discuss nucleic acids, genes, and gene products; replication, translation, and transcription; posttranslational modifications of gene products and protein degradation; transcription factors, cell surface receptors and signaling pathways, the cell cycle, apoptosis, cell survival and DNA damage repair; mutations; and microRNAs and siRNAs.

Original languageEnglish (US)
Title of host publicationDail and Hammar's Pulmonary Pathology
Subtitle of host publicationThird Edition
PublisherSpringer New York
Pages47-157
Number of pages111
Volume2
ISBN (Print)9780387721132
DOIs
StatePublished - Dec 1 2008

ASJC Scopus subject areas

  • Medicine(all)

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    Cagle, P. T., Jagirdar, J., & Popper, H. H. (2008). Molecular genetics of lung and pleural neoplasms. In Dail and Hammar's Pulmonary Pathology: Third Edition (Vol. 2, pp. 47-157). Springer New York. https://doi.org/10.1007/978-0-387-72114-9_2