Abstract
Molecular pathology involves study of nucleic acids, genes, and gene products.1-9 The development and progression of human cancers are linked to genetic instability and the accumulation of multiple genetic mutations, which can be investigated with the tools of molecular pathology.10-25 Molecular pathology provides a basis for understanding the biology of lung cancer,26-36 including its pathogenetic relationship to tobacco smoking,37-57 and increasingly is providing targets for therapeutic intervention. 58-78 In this section, we briefly review the basic terminology and concepts, as an introduction or refresher to subsequent sections of this chapter, and we discuss nucleic acids, genes, and gene products; replication, translation, and transcription; posttranslational modifications of gene products and protein degradation; transcription factors, cell surface receptors and signaling pathways, the cell cycle, apoptosis, cell survival and DNA damage repair; mutations; and microRNAs and siRNAs.
Original language | English (US) |
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Title of host publication | Dail and Hammar's Pulmonary Pathology |
Subtitle of host publication | Third Edition |
Publisher | Springer New York |
Pages | 47-157 |
Number of pages | 111 |
Volume | 2 |
ISBN (Print) | 9780387721132 |
DOIs | |
State | Published - 2008 |
Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)