Molecular evolution of the human interleukin−8 receptor gene cluster

Sunil K. Ahuja, Tayfun Özçelik, Athena Milatovitch, Uta Francke, Philip M. Murphy

Research output: Contribution to journalArticle

93 Scopus citations

Abstract

Interleukin−8 (IL−8) is the prototype for a family of at least eight neutrophil chemoattractants whose genes map to human chromosome 4q13−q21. Two human IL−8 receptors, IL8RA and IL8RB, are known from cDNA cloning; IL8RA is a promiscuous receptor for at least two other related ligands, GROalpha and NAP−2. We now report cloning of the genes for IL8RA, IL8RB and a recently inactivated pseudogene of receptor A (IL8RAP). These form a cluster of only three genes in the superfamily of G protein−coupled receptors (GPCRs) and map to 2q34−q35. The revolutionary diversity displayed by the IL−8 ligand−receptor complex — ligand promiscuity for IL−8, receptor promiscuity for IL8RA, gene duplication for both ligands and receptors and gene extinction in the case of IL8RAP — is unprecedented for the GPCR superfamily.

Original languageEnglish (US)
Pages (from-to)31-36
Number of pages6
JournalNature Genetics
Volume2
Issue number1
DOIs
StatePublished - Sep 1992

ASJC Scopus subject areas

  • Genetics

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    Ahuja, S. K., Özçelik, T., Milatovitch, A., Francke, U., & Murphy, P. M. (1992). Molecular evolution of the human interleukin−8 receptor gene cluster. Nature Genetics, 2(1), 31-36. https://doi.org/10.1038/ng0992-31