Molecular evolution of growth hormone and receptor in the guinea-pig, a mammal unresponsive to growth hormone

Ronald M. Adkins, John Vandeberg, Wen Hsiung Li

    Research output: Contribution to journalArticle

    12 Scopus citations

    Abstract

    Growth in the guinea-pig is completely unresponsive to endogenous or exogenous growth hormone, despite the fact that the guinea-pig produces normal to high levels of growth hormone and receptor. In primates and artiodactyls, growth hormone exhibits accelerated rates of evolution that appear to be correlated with changes in function. Surprisingly, both guinea-pig growth hormone and receptor exhibit slow rates of evolution similar to those seen in other mammals, implying that both proteins are as functionally conserved in the guinea-pig as in other mammals or that any loss or relaxation of functional constraint was very recent. However, the guinea-pig growth hormone and receptor both exhibit a single amino acid replacement at a site known to have functional significance. Nevertheless, it is unclear whether the aberrant nature of the guinea-pig growth hormone-growth hormone receptor axis is due to these replacements or whether it is due to a defect in post-receptor signalling. (C) 2000 Elsevier Science B.V. All rights reserved.

    Original languageEnglish (US)
    Pages (from-to)357-363
    Number of pages7
    JournalGene
    Volume246
    Issue number1-2
    DOIs
    StatePublished - Apr 4 2000

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    Keywords

    • Growth hormone receptor
    • Opossum
    • Species specificity

    ASJC Scopus subject areas

    • Genetics

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