TY - JOUR
T1 - Molecular differential pathology of rhabdomyosarcoma
AU - Scrable, Heidi
AU - Witte, David
AU - Shimada, Hiroyuki
AU - Seemayer, Thomas
AU - Wang‐Wuu, Sheng
AU - Soukup, Shirley
AU - Koufos, Alex
AU - Houghton, Peter
AU - Lampkin, Beatrice
AU - Cavenee, Webster
PY - 1989/9
Y1 - 1989/9
N2 - Tumors of the soft tissues are classified histogenetically according to their phenotypic resemblance to normal adult tissue. Here we describe molecular approaches that make it possible to distinguish between one class of these tumors, rhabdomyosarcoma, and other small‐, round‐cell tumors. We show that the ascertainment of specific genotypic changes can be used to distinguish further between the embryonal and alveolar subtypes of rhabdomyosarcoma. We tested our model in two ways: first, in a retrospective analysis of diagnostically problematic cases of undifferentiated, small‐cell tumors and, second, in a blind study of pediatric tumors. Rhabdomyosarcoma was correctly identified in all cases using this strategy alone. The underlying simplicity of the strategy used to define rhabdomyosarcoma subtypes with molecular markers suggests a model by which tumors can be unequivocally identified, which may apply equally well to other human solid tumors.
AB - Tumors of the soft tissues are classified histogenetically according to their phenotypic resemblance to normal adult tissue. Here we describe molecular approaches that make it possible to distinguish between one class of these tumors, rhabdomyosarcoma, and other small‐, round‐cell tumors. We show that the ascertainment of specific genotypic changes can be used to distinguish further between the embryonal and alveolar subtypes of rhabdomyosarcoma. We tested our model in two ways: first, in a retrospective analysis of diagnostically problematic cases of undifferentiated, small‐cell tumors and, second, in a blind study of pediatric tumors. Rhabdomyosarcoma was correctly identified in all cases using this strategy alone. The underlying simplicity of the strategy used to define rhabdomyosarcoma subtypes with molecular markers suggests a model by which tumors can be unequivocally identified, which may apply equally well to other human solid tumors.
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U2 - 10.1002/gcc.2870010106
DO - 10.1002/gcc.2870010106
M3 - Article
C2 - 2487144
AN - SCOPUS:0024958667
SN - 1045-2257
VL - 1
SP - 23
EP - 35
JO - Genes, Chromosomes and Cancer
JF - Genes, Chromosomes and Cancer
IS - 1
ER -