Molecular differential pathology of rhabdomyosarcoma

Heidi Scrable, David Witte, Hiroyuki Shimada, Thomas Seemayer, Sheng Wang‐Wuu, Shirley Soukup, Alex Koufos, Peter J Houghton, Beatrice Lampkin, Webster Cavenee

Research output: Contribution to journalArticle

171 Citations (Scopus)

Abstract

Tumors of the soft tissues are classified histogenetically according to their phenotypic resemblance to normal adult tissue. Here we describe molecular approaches that make it possible to distinguish between one class of these tumors, rhabdomyosarcoma, and other small‐, round‐cell tumors. We show that the ascertainment of specific genotypic changes can be used to distinguish further between the embryonal and alveolar subtypes of rhabdomyosarcoma. We tested our model in two ways: first, in a retrospective analysis of diagnostically problematic cases of undifferentiated, small‐cell tumors and, second, in a blind study of pediatric tumors. Rhabdomyosarcoma was correctly identified in all cases using this strategy alone. The underlying simplicity of the strategy used to define rhabdomyosarcoma subtypes with molecular markers suggests a model by which tumors can be unequivocally identified, which may apply equally well to other human solid tumors.

Original languageEnglish (US)
Pages (from-to)23-35
Number of pages13
JournalGenes, Chromosomes and Cancer
Volume1
Issue number1
DOIs
StatePublished - Jan 1 1989
Externally publishedYes

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Molecular Pathology
Rhabdomyosarcoma
Neoplasms
Alveolar Rhabdomyosarcoma
Pediatrics

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

Cite this

Scrable, H., Witte, D., Shimada, H., Seemayer, T., Wang‐Wuu, S., Soukup, S., ... Cavenee, W. (1989). Molecular differential pathology of rhabdomyosarcoma. Genes, Chromosomes and Cancer, 1(1), 23-35. https://doi.org/10.1002/gcc.2870010106

Molecular differential pathology of rhabdomyosarcoma. / Scrable, Heidi; Witte, David; Shimada, Hiroyuki; Seemayer, Thomas; Wang‐Wuu, Sheng; Soukup, Shirley; Koufos, Alex; Houghton, Peter J; Lampkin, Beatrice; Cavenee, Webster.

In: Genes, Chromosomes and Cancer, Vol. 1, No. 1, 01.01.1989, p. 23-35.

Research output: Contribution to journalArticle

Scrable, H, Witte, D, Shimada, H, Seemayer, T, Wang‐Wuu, S, Soukup, S, Koufos, A, Houghton, PJ, Lampkin, B & Cavenee, W 1989, 'Molecular differential pathology of rhabdomyosarcoma', Genes, Chromosomes and Cancer, vol. 1, no. 1, pp. 23-35. https://doi.org/10.1002/gcc.2870010106
Scrable H, Witte D, Shimada H, Seemayer T, Wang‐Wuu S, Soukup S et al. Molecular differential pathology of rhabdomyosarcoma. Genes, Chromosomes and Cancer. 1989 Jan 1;1(1):23-35. https://doi.org/10.1002/gcc.2870010106
Scrable, Heidi ; Witte, David ; Shimada, Hiroyuki ; Seemayer, Thomas ; Wang‐Wuu, Sheng ; Soukup, Shirley ; Koufos, Alex ; Houghton, Peter J ; Lampkin, Beatrice ; Cavenee, Webster. / Molecular differential pathology of rhabdomyosarcoma. In: Genes, Chromosomes and Cancer. 1989 ; Vol. 1, No. 1. pp. 23-35.
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