Molecular determinants of the virulence and infectivity of California serogroup bunyaviruses

Christian Griot, Francisco Gonzalez-Scarano, Neal Nathanson

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

California bunyaviruses cause encephalitis in mammalian hosts after peripheral infection. The virulence of these viruses is determined by their ability to replicate sequentially in striated muscle, cause viremia, and invade and replicate in the central nervous system. These viruses are also able to infect vector mosquitoes following ingestion of a blood meal containing virus. Bunyaviruses are negative stranded RNA viruses with a trisegmented genome, and the large, medium, and small RNA segments encode the polymerase, the glycoproteins, and the nucleoprotein, respectively. Reassortants between virulent and avirulent virus clones have been used to map virulence determinants in mice as well as determinants of infectivity in mosquitoes. Attenuation in mice and infectivity in mosquitoes of some virus clones maps to the medium RNA segment, implying that the virus glycoproteins, which are involved in virus entry, play a role in virulence. Attenuation in mice and mosquito infectivity of other clones maps to the large RNA segment, suggesting that cell-specific differences in the function of the viral polymerase can also determine virulence and host range.

Original languageEnglish (US)
Pages (from-to)117-138
Number of pages22
JournalAnnual Review of Microbiology
Volume47
StatePublished - 1993
Externally publishedYes

Fingerprint

Orthobunyavirus
Virulence
Viruses
Culicidae
Clone Cells
RNA
Glycoproteins
Virus Internalization
Nucleoproteins
Striated Muscle
Host Specificity
Viremia
RNA Viruses
Encephalitis
Meals
Serogroup
Central Nervous System
Eating
Genome
Infection

Keywords

  • animal models
  • arboviruses
  • California serogroup viruses
  • virus genetics

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Microbiology

Cite this

Molecular determinants of the virulence and infectivity of California serogroup bunyaviruses. / Griot, Christian; Gonzalez-Scarano, Francisco; Nathanson, Neal.

In: Annual Review of Microbiology, Vol. 47, 1993, p. 117-138.

Research output: Contribution to journalArticle

Griot, Christian ; Gonzalez-Scarano, Francisco ; Nathanson, Neal. / Molecular determinants of the virulence and infectivity of California serogroup bunyaviruses. In: Annual Review of Microbiology. 1993 ; Vol. 47. pp. 117-138.
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