Molecular determinants of insulin action

C. R. Kahn, F. Folli

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Insulin rapidly stimulates tyrosine phosphorylation of a 185-kDa protein in most cell types. This protein, insulin receptor substrate 1 (IRS-1), has been implicated as the first postreceptor step in insulin signal transmission based on studies with insulin receptor mutants. In cell culture and in vitro, phosphory-lated IRS-1 associates with the lipid-metabolizing enzyme phosphatidylinosi-tol 3-kinase (PI 3-kinase), resulting in activation of this enzyme. Thus, the insulin receptor, IRS-1 and PI-3 kinase represent three of the earliest steps in insulin action at the cellular level. We have recently demonstrated that insulin is capable of stimulating PI 3-kinase activity in liver and muscle in vivo in animals and that IRS-1 phosphorylation may play a significant role in the association/activation with PI 3-kinase in vivo.

Original languageEnglish (US)
Pages (from-to)93-101
Number of pages9
JournalHormone Research in Paediatrics
StatePublished - 1993


  • Insulin
  • Insulin receptor substrate 1
  • Insulin receptors
  • Phosphoinositol 3-kinase
  • Phosphorylation

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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