Molecular cloning and characterization of WD40-repeat protein from Clonorchis sinensis

Pyo Yun Cho, Tea Im Kim, Won Gi Yoo, Shunyu Li, Sung Jong Hong, Tae Yun Kim, Young Soon Park, Kye Yong Song, Min Ho Choi, Sung Tae Hong, Yong Je Chung, Philip T. LoVerde, Ahmed Osman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

WD40-repeat proteins have four to eight repeating units flanked by Gly-His (GH) and Trp-Asp (WD) at both termini and folds into a β-propeller. A polypeptide deduced from a Clonorchis sinensis cDNA clone analyzed to have seven WD40-repeats and predicted to form a β-propeller (CsWD1). The CsWD1 protein was expressed stage-specifically in the metacercariae and localized in the tegumental syncytium. The CsWD1 protein is suggested to serve as a platform for interacting partner proteins in the tegumental syncytium of C. sinensis metacercariae.

Original languageEnglish (US)
Pages (from-to)53-56
Number of pages4
JournalParasitology Research
Volume102
Issue number1
DOIs
StatePublished - Dec 1 2007

ASJC Scopus subject areas

  • Parasitology
  • veterinary(all)
  • Insect Science
  • Infectious Diseases

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