Molecular characterization of the prototrophic Salmonella mutants defective for intraepithelial replication

Akamol E. Suvarnapunya, Daniel V. Zurawski, Rebecca L. Guy, Murry A. Stein

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Three MudJ prototrophs demonstrated that intracellular replication is a Salmonella virulence trait (K. Y. Leung and B. B. Finlay, Proc. Natl. Acad. Sci. USA, 88:11470-11474, 1991). mutS and mutH are disrupted in mutants 3-11 and 12-23, and ssaQ is disrupted in mutant 17-21. Further analysis revealed that loss of Salmonella pathogenicity island 2 function underlies the intracellular replication defect of 3-11 and 17-21.

Original languageEnglish (US)
Pages (from-to)2247-2252
Number of pages6
JournalInfection and immunity
Volume71
Issue number4
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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