Molecular aspects of thyroid cancer in children

Research output: Chapter in Book/Report/Conference proceedingChapter


Children with thyroid cancer generally have a more favorable prognosis than adults. This chapter reviews the data that suggest the pattern of ret/PTC, BRAF, and RAS mutations might differ in papillary thyroid carcinoma (PTC) from children and adults. Expression of the insulin-like growth factors (IGFs) and IGF receptors may also differ, as well as the intensity or nature of the immune response. Additional study is warranted to better define the impact of each of these factors on the clinical behavior of thyroid cancers in children.

Original languageEnglish (US)
Title of host publicationThyroid Cancer (Second Edition)
Subtitle of host publicationA Comprehensive Guide to Clinical Management
PublisherHumana Press
Number of pages7
ISBN (Print)9781588294623
StatePublished - Dec 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)


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