Molecular and virologic characteristics of lymphoid malignancies in children with AIDS

Kenneth L. McClain, Charles T. Leach, Hal B. Jenson, Vijay V. Joshi, Brad H. Pollock, Robert E. Hutchison, Sharon B. Murphy

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

Purpose: To characterize AIDS-associated lymphoid malignancies in children. Patients and Methods: We studied lymphomas and B-cell leukemias from 25 children with AIDS for immunoglobulin heavy chain gene clonality, c- myc oncogene abnormalities, and presence of HIV and Epstein-Bart virus. Results: Monoclonal immunoglobulin gene rearrangements were identified in 22 of 23 cases tested, the single exception being one of mucosa-associated lymphoid tissue. Immunoglobulin gene/c-myc translocations were found in 3 of 4 cases of B (surface immunoglobulin-positive)-acute lymphoblastic leukemia, 8 of 11 small noncleaved cell lymphomas, and 1 of 5 large cell lymphomas. Mutations of c-myc were found in 2 of 13 small noncleaved cell lymphomas, 1 of 2 Epstein-Barr virus-positive mucosa-associated lymphoid tissue neoplasms, and 1 of 4 Epstein-Barr virus-negative B-acute lymphoblastic leukemia. Six small noncleaved cell lymphomas, both mucosa-associated lymphoid tissue neoplasms and one of large cell lymphoma had high levels of Epstein-Barr virus in tumor tissue. Hodgkin's disease tissue and B-acute lymphoblastic leukemia tumors were negative for EBV. Proviral HIV-1 was not detected in any tumor. Conclusions: AIDS-associated lymphoid malignancies in children appear to have a different distribution of histologic subtypes than adult HIV- infected individuals, fewer large cell lymphomas occur in children. The small noncleaved cell lymphomas exhibit a lower frequency as well as different locations of c-myc mutations than AIDS-associated small noncleaved cell lymphomas in adults.

Original languageEnglish (US)
Pages (from-to)152-159
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume23
Issue number2
DOIs
StatePublished - Feb 1 2000
Externally publishedYes

Keywords

  • AIDS-associated lymphomas
  • Children
  • EBV
  • Immunoglobulin gene
  • myc

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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