Modulation of taxane binding to tubulin curved and straight conformations by systematic 3′N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency

Yuntao Ma, Fernando Josa-Prado, Jacob Nathaniel Essif, Shuqi Liu, Shuo Li, Daniel Lucena-Agell, Peter YW Chan, Kenneth Goossens, Rafael Hortigüela, Ruth Matesanz, Yingjie Wang, Federico Gago, Hongbo Wang, April Risinger, J. Fernando Diaz, Wei Shuo Fang

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Biochemistry, Genetics and Molecular Biology

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