@article{63374f2bc8574b24a3ff9a532675c873,
title = "Modulation of longevity and tissue homeostasis by the drosophila PGC-1 homolog",
abstract = "In mammals, the PGC-1 transcriptional coactivators are key regulators of energy metabolism, including mitochondrial biogenesis and respiration, which have been implicated in numerous pathogenic conditions, including neurodegeneration and cardiomyopathy. Here, we show that overexpression of the Drosophila PGC-1 homolog (dPGC-1/spargel) is sufficient to increase mitochondrial activity. Moreover, tissue-specific overexpression of dPGC-1 in stem and progenitor cells within the digestive tract extends life span. Long-lived flies overexpressing dPGC-1 display a delay in the onset of aging-related changes in the intestine, leading to improved tissue homeostasis in old flies. Together, these results demonstrate that dPGC-1 can slow aging both at the level of cellular changes in an individual tissue and also at the organismal level by extending life span. Our findings point to the possibility that alterations in PGC-1 activity in high-turnover tissues, such as the intestine, may be an important determinant of longevity in mammals.",
author = "Michael Rera and Sepehr Bahadorani and Jaehyoung Cho and Koehler, {Christopher L.} and Matthew Ulgherait and Hur, {Jae H.} and Ansari, {William S.} and Thomas Lo and Jones, {D. Leanne} and Walker, {David W.}",
note = "Funding Information: The authors would like to thank Kevin Vu, Kent Vu, Holly Vu, and Jeff Copeland for help with fly work and generation of UAS constructs. We also thank H. Keshishian, S. Pletcher, L. Seroude, H. Jasper, and the Drosophila Stock Center (Bloomington) for fly stocks. D.L.J. is funded by the Emerald Foundation, the G. Harold and Leila Y. Mathers Charitable Foundation, the American Cancer Society, the California Institute for Regenerative Medicine, and the National Institutes of Health (NIH; R01 AG028092). C.K. was funded by an NIH Developmental Biology training grant (2T32HD007495, C. Kintner). M.U. is supported by a Ruth L. Kirschstein National Research Service Award (GM07185). D.W.W is funded by the National Institute on Aging (RO1 AG037514) and the Ellison Medical Foundation. D.W.W also received support from the University of California, Los Angeles Older Americans Independence Center, and NIH/National Institute on Aging (NIA) grant P30-AG028748, and the content does not necessarily represent the official views of the NIA or the NIH. D.W.W is an Ellison Medical Foundation New Scholar in Aging. ",
year = "2011",
month = nov,
day = "2",
doi = "10.1016/j.cmet.2011.09.013",
language = "English (US)",
volume = "14",
pages = "623--634",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "5",
}